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- NCIT_C61711 IAO_0000115 "A racemic mixture of propoxyphene, a synthetic opiate agonist with narcotic analgesic activity. The analgesic effect of propoxyphene is due to its d-isomer, dextropropoxyphene, which bind to opiate receptors, primarily the OP3 receptor located within the central nervous system (CNS). Mediated through G-protein coupled OP3 receptors and cAMP signaling, the release of nociceptive neurotransmitters such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline is inhibited. Propoxyphene also inhibits the release of vasopressin, somatostatin, insulin and glucagon and close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability." @default.
- NCIT_C61711 NCIT_NHC0 "C61711" @default.
- NCIT_C61711 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61711 NCIT_P108 "Propoxyphene, (+/-)-" @default.
- NCIT_C61711 NCIT_P207 "C1880235" @default.
- NCIT_C61711 NCIT_P210 "2621-61-6" @default.
- NCIT_C61711 NCIT_P319 "II2G62OV6F" @default.
- NCIT_C61711 NCIT_P322 "FDA" @default.
- NCIT_C61711 NCIT_P350 "C22H29NO2" @default.
- NCIT_C61711 NCIT_P366 "DL-Propoxyphene" @default.
- NCIT_C61711 normalizedInformationContent "100" @default.
- NCIT_C61711 referenceCount "1" @default.
- NCIT_C61711 hasExactSynonym "DL-Propoxyphene" @default.
- NCIT_C61711 hasExactSynonym "PROPOXYPHENE, (+/-)-" @default.
- NCIT_C61711 hasExactSynonym "Propoxyphene, (+/-)-" @default.
- NCIT_C61711 inSubset NCIT_C63923 @default.
- NCIT_C61711 type Class @default.
- NCIT_C61711 isDefinedBy ncit.owl @default.
- NCIT_C61711 label "Propoxyphene, (+/-)-" @default.
- NCIT_C61711 subClassOf NCIT_C1908 @default.
- NCIT_C61711 subClassOf NCIT_C1909 @default.
- NCIT_C61711 subClassOf NCIT_C241 @default.
- NCIT_C61711 subClassOf NCIT_C61711 @default.
- NCIT_C61711 subClassOf NCIT_C67413 @default.
- NCIT_C61711 subClassOf NCIT_C78272 @default.