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- NCIT_C61735 IAO_0000115 "An indole derivative and a potent serotonin 5-HT3 receptor antagonist with anti-emetic property. Dolasetron blocks the activity of serotonin released from the enterochromaffin cells of the small intestine by selectively inhibiting and inactivating 5-HT3 receptors located on the nerve terminals of the vagus nerve in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. This results in suppression of signalling to trigger chemo- and radiotherapy induced nausea and vomiting." @default.
- NCIT_C61735 NCIT_A5 NCIT_C1153 @default.
- NCIT_C61735 NCIT_NHC0 "C61735" @default.
- NCIT_C61735 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61735 NCIT_P108 "Dolasetron" @default.
- NCIT_C61735 NCIT_P207 "C0209210" @default.
- NCIT_C61735 NCIT_P210 "115956-12-2" @default.
- NCIT_C61735 NCIT_P319 "82WI2L7Q6E" @default.
- NCIT_C61735 NCIT_P322 "FDA" @default.
- NCIT_C61735 NCIT_P325 "The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Dolasetron is a type of serotonin receptor antagonist and a type of antiemetic." @default.
- NCIT_C61735 NCIT_P350 "C19H20N2O3" @default.
- NCIT_C61735 NCIT_P366 "Dolasetron" @default.
- NCIT_C61735 NCIT_P368 "CHEBI:4682" @default.
- NCIT_C61735 normalizedInformationContent "100" @default.
- NCIT_C61735 referenceCount "1" @default.
- NCIT_C61735 hasExactSynonym "DOLASETRON" @default.
- NCIT_C61735 hasExactSynonym "Dolasetron" @default.
- NCIT_C61735 hasExactSynonym "dolasetron" @default.
- NCIT_C61735 inSubset NCIT_C63923 @default.
- NCIT_C61735 type Class @default.
- NCIT_C61735 isDefinedBy ncit.owl @default.
- NCIT_C61735 label "Dolasetron" @default.
- NCIT_C61735 subClassOf NCIT_C1908 @default.
- NCIT_C61735 subClassOf NCIT_C1909 @default.
- NCIT_C61735 subClassOf NCIT_C267 @default.
- NCIT_C61735 subClassOf NCIT_C61735 @default.
- NCIT_C61735 subClassOf NCIT_C66885 @default.
- NCIT_C61735 subClassOf NCIT_C78272 @default.
- NCIT_C61735 subClassOf NCIT_C94726 @default.