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- NCIT_C61738 IAO_0000115 "A first generation ethanolamine with antiinflammatory, sedative and antihistamine properties. Doxylamine competitively inhibits the histamine 1 (H1) receptor, thereby preventing the action of endogenous histamine as well as the subsequent release of pro-inflammatory mediators from basophils and mast cells. This agent acts as an inverse agonist that combines with, and stabilizes the inactive form of the H1-receptor, shifting the H1 receptor equilibrium toward the inactive state. This results in downregulation of nuclear factor-kappaB (NF-kappaB) and NF-kappaB dependent antigen presentation, chemotaxis, as well as expression of cell-adhesion molecules and pro-inflammatory cytokines." @default.
- NCIT_C61738 NCIT_A5 NCIT_C47501 @default.
- NCIT_C61738 NCIT_NHC0 "C61738" @default.
- NCIT_C61738 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61738 NCIT_P108 "Doxylamine" @default.
- NCIT_C61738 NCIT_P207 "C0013092" @default.
- NCIT_C61738 NCIT_P210 "469-21-6" @default.
- NCIT_C61738 NCIT_P319 "95QB77JKPL" @default.
- NCIT_C61738 NCIT_P322 "FDA" @default.
- NCIT_C61738 NCIT_P350 "C17H22N2O" @default.
- NCIT_C61738 NCIT_P366 "Doxylamine" @default.
- NCIT_C61738 NCIT_P368 "CHEBI:51380" @default.
- NCIT_C61738 normalizedInformationContent "100" @default.
- NCIT_C61738 referenceCount "1" @default.
- NCIT_C61738 hasExactSynonym "DOXYLAMINE" @default.
- NCIT_C61738 hasExactSynonym "Doxylamine" @default.
- NCIT_C61738 inSubset NCIT_C63923 @default.
- NCIT_C61738 type Class @default.
- NCIT_C61738 isDefinedBy ncit.owl @default.
- NCIT_C61738 label "Doxylamine" @default.
- NCIT_C61738 subClassOf NCIT_C1908 @default.
- NCIT_C61738 subClassOf NCIT_C1909 @default.
- NCIT_C61738 subClassOf NCIT_C29578 @default.
- NCIT_C61738 subClassOf NCIT_C308 @default.
- NCIT_C61738 subClassOf NCIT_C61738 @default.