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- NCIT_C61754 IAO_0000115 "The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties. Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors. Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding." @default.
- NCIT_C61754 NCIT_A5 NCIT_C47518 @default.
- NCIT_C61754 NCIT_A7 NCIT_C105876 @default.
- NCIT_C61754 NCIT_NHC0 "C61754" @default.
- NCIT_C61754 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61754 NCIT_P107 "Escitalopram" @default.
- NCIT_C61754 NCIT_P108 "Escitalopram" @default.
- NCIT_C61754 NCIT_P207 "C1099456" @default.
- NCIT_C61754 NCIT_P210 "128196-01-0" @default.
- NCIT_C61754 NCIT_P319 "4O4S742ANY" @default.
- NCIT_C61754 NCIT_P322 "CTRP" @default.
- NCIT_C61754 NCIT_P322 "FDA" @default.
- NCIT_C61754 NCIT_P325 "A drug used to treat depression and certain anxiety disorders. It belongs to the family of drugs called selective serotonin reuptake inhibitors (SSRIs)." @default.
- NCIT_C61754 NCIT_P350 "C20H21FN2O" @default.
- NCIT_C61754 NCIT_P366 "Escitalopram" @default.
- NCIT_C61754 NCIT_P368 "CHEBI:36791" @default.
- NCIT_C61754 normalizedInformationContent "100" @default.
- NCIT_C61754 referenceCount "1" @default.
- NCIT_C61754 hasExactSynonym "(S)-Citalopram" @default.
- NCIT_C61754 hasExactSynonym "ESCITALOPRAM" @default.
- NCIT_C61754 hasExactSynonym "Escitalopram" @default.
- NCIT_C61754 hasExactSynonym "S(+)-Citalopram" @default.
- NCIT_C61754 hasExactSynonym "Seroplex" @default.
- NCIT_C61754 hasExactSynonym "escitalopram" @default.
- NCIT_C61754 inSubset NCIT_C116977 @default.
- NCIT_C61754 inSubset NCIT_C116978 @default.
- NCIT_C61754 inSubset NCIT_C63923 @default.
- NCIT_C61754 type Class @default.
- NCIT_C61754 isDefinedBy ncit.owl @default.
- NCIT_C61754 label "Escitalopram" @default.
- NCIT_C61754 subClassOf NCIT_C1908 @default.
- NCIT_C61754 subClassOf NCIT_C1909 @default.
- NCIT_C61754 subClassOf NCIT_C265 @default.
- NCIT_C61754 subClassOf NCIT_C61754 @default.
- NCIT_C61754 subClassOf NCIT_C78272 @default.
- NCIT_C61754 subClassOf NCIT_C94725 @default.