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- NCIT_C61762 IAO_0000115 "The hydrochloride salt form of fentanyl, a synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of fentanyl is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability." @default.
- NCIT_C61762 NCIT_A6 NCIT_C494 @default.
- NCIT_C61762 NCIT_NHC0 "C61762" @default.
- NCIT_C61762 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61762 NCIT_P108 "Fentanyl Hydrochloride" @default.
- NCIT_C61762 NCIT_P207 "C1726021" @default.
- NCIT_C61762 NCIT_P210 "1443-54-5" @default.
- NCIT_C61762 NCIT_P319 "59H156XY46" @default.
- NCIT_C61762 NCIT_P322 "FDA" @default.
- NCIT_C61762 NCIT_P350 "C22H28N2O.HCl" @default.
- NCIT_C61762 NCIT_P366 "Fentanyl_Hydrochloride" @default.
- NCIT_C61762 normalizedInformationContent "100" @default.
- NCIT_C61762 referenceCount "1" @default.
- NCIT_C61762 hasExactSynonym "FENTANYL HYDROCHLORIDE" @default.
- NCIT_C61762 hasExactSynonym "Fentanyl Hydrochloride" @default.
- NCIT_C61762 hasExactSynonym "Ionsys" @default.
- NCIT_C61762 inSubset NCIT_C63923 @default.
- NCIT_C61762 type Class @default.
- NCIT_C61762 isDefinedBy ncit.owl @default.
- NCIT_C61762 label "Fentanyl Hydrochloride" @default.
- NCIT_C61762 subClassOf NCIT_C1506 @default.
- NCIT_C61762 subClassOf NCIT_C1908 @default.
- NCIT_C61762 subClassOf NCIT_C1909 @default.
- NCIT_C61762 subClassOf NCIT_C1913 @default.
- NCIT_C61762 subClassOf NCIT_C1916 @default.
- NCIT_C61762 subClassOf NCIT_C221 @default.
- NCIT_C61762 subClassOf NCIT_C61762 @default.
- NCIT_C61762 subClassOf NCIT_C67413 @default.
- NCIT_C61762 subClassOf NCIT_C718 @default.
- NCIT_C61762 subClassOf NCIT_C78272 @default.