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- NCIT_C61764 IAO_0000115 "A second generation, long-lasting selective histamine H1 receptor antagonist with antiinflammatory property. Fexofenadine is a highly selective and reversible competitor at peripheral H1 histamine receptors in the gastrointestinal (GI) tract, blood vessels, and bronchial smooth muscle. This agent interferes with mediators release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition fexofenadine may also inhibit the late-phase allergic reaction by acting on leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Overall, this agent blocks the actions of endogenous histamine, thereby leads to temporary relief of the negative symptoms associated with histamine and achieve effects such as decreased vascular permeability, reduction of pruritus and localized smooth muscle relaxation." @default.
- NCIT_C61764 NCIT_A5 NCIT_C29050 @default.
- NCIT_C61764 NCIT_NHC0 "C61764" @default.
- NCIT_C61764 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61764 NCIT_P108 "Fexofenadine" @default.
- NCIT_C61764 NCIT_P207 "C0296800" @default.
- NCIT_C61764 NCIT_P210 "83799-24-0" @default.
- NCIT_C61764 NCIT_P319 "E6582LOH6V" @default.
- NCIT_C61764 NCIT_P322 "FDA" @default.
- NCIT_C61764 NCIT_P325 "A drug used to treat certain allergy symptoms. It blocks a chemical released during an allergic response that causes itching, sneezing, runny nose, wheezing, and watery eyes. It is a type of antihistamine." @default.
- NCIT_C61764 NCIT_P350 "C32H39NO4" @default.
- NCIT_C61764 NCIT_P366 "Fexofenadine" @default.
- NCIT_C61764 NCIT_P368 "CHEBI:5050" @default.
- NCIT_C61764 normalizedInformationContent "100" @default.
- NCIT_C61764 referenceCount "1" @default.
- NCIT_C61764 hasExactSynonym "FEXOFENADINE" @default.
- NCIT_C61764 hasExactSynonym "Fexofenadine" @default.
- NCIT_C61764 hasExactSynonym "fexofenadine" @default.
- NCIT_C61764 inSubset NCIT_C63923 @default.
- NCIT_C61764 type Class @default.
- NCIT_C61764 isDefinedBy ncit.owl @default.
- NCIT_C61764 label "Fexofenadine" @default.
- NCIT_C61764 subClassOf NCIT_C1908 @default.
- NCIT_C61764 subClassOf NCIT_C1909 @default.
- NCIT_C61764 subClassOf NCIT_C29578 @default.
- NCIT_C61764 subClassOf NCIT_C308 @default.
- NCIT_C61764 subClassOf NCIT_C61764 @default.