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- NCIT_C61775 IAO_0000115 "A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens." @default.
- NCIT_C61775 NCIT_A5 NCIT_C47548 @default.
- NCIT_C61775 NCIT_NHC0 "C61775" @default.
- NCIT_C61775 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61775 NCIT_P108 "Gemifloxacin" @default.
- NCIT_C61775 NCIT_P207 "C0533545" @default.
- NCIT_C61775 NCIT_P210 "175463-14-6" @default.
- NCIT_C61775 NCIT_P210 "204519-64-2" @default.
- NCIT_C61775 NCIT_P319 "OKR68Y0E4T" @default.
- NCIT_C61775 NCIT_P322 "FDA" @default.
- NCIT_C61775 NCIT_P350 "C18H20FN5O4" @default.
- NCIT_C61775 NCIT_P366 "Gemifloxacin" @default.
- NCIT_C61775 NCIT_P368 "CHEBI:101853" @default.
- NCIT_C61775 normalizedInformationContent "100" @default.
- NCIT_C61775 referenceCount "1" @default.
- NCIT_C61775 hasExactSynonym "GEMIFLOXACIN" @default.
- NCIT_C61775 hasExactSynonym "Gemifloxacin" @default.
- NCIT_C61775 inSubset NCIT_C63923 @default.
- NCIT_C61775 type Class @default.
- NCIT_C61775 isDefinedBy ncit.owl @default.
- NCIT_C61775 label "Gemifloxacin" @default.
- NCIT_C61775 subClassOf NCIT_C1908 @default.
- NCIT_C61775 subClassOf NCIT_C1909 @default.
- NCIT_C61775 subClassOf NCIT_C254 @default.
- NCIT_C61775 subClassOf NCIT_C258 @default.
- NCIT_C61775 subClassOf NCIT_C61775 @default.
- NCIT_C61775 subClassOf NCIT_C795 @default.