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- NCIT_C61812 IAO_0000115 "The citrate salt of lithium, a monovalent cation with antimanic activity. Although the exact mechanism is unclear, lithium might exert its mood-stabilizing effect via reduction of catecholamine concentration mediated through transneuronal membrane transport of sodium ion by sodium-potassium-stimulated adenosine triphosphatase (Na-K-ATPase). Alternatively, lithium may decrease cyclic adenosine monophosphate (cAMP) concentrations, which would desensitize hormonal-sensitive adenylyl cyclase receptors. Furthermore, lithium, in recommended dosage, blocks the activity of inositol-1-phosphatase, thereby resulting in the subsequent decrease of postsynaptic second messengers, diacylglycerol and inositol triphosphate, that contribute to chronic cell stimulation by altering electrical activity in the neuron." @default.
- NCIT_C61812 NCIT_NHC0 "C61812" @default.
- NCIT_C61812 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61812 NCIT_P108 "Lithium Citrate" @default.
- NCIT_C61812 NCIT_P207 "C0125997" @default.
- NCIT_C61812 NCIT_P210 "6080-58-6" @default.
- NCIT_C61812 NCIT_P319 "5Z6E9K79YV" @default.
- NCIT_C61812 NCIT_P322 "FDA" @default.
- NCIT_C61812 NCIT_P350 "C6H5O7.3Li.4H2O" @default.
- NCIT_C61812 NCIT_P366 "Lithium_Citrate" @default.
- NCIT_C61812 NCIT_P368 "CHEBI:64754" @default.
- NCIT_C61812 normalizedInformationContent "100" @default.
- NCIT_C61812 referenceCount "1" @default.
- NCIT_C61812 hasExactSynonym "LITHIUM CITRATE" @default.
- NCIT_C61812 hasExactSynonym "Lithium Citrate" @default.
- NCIT_C61812 inSubset NCIT_C63923 @default.
- NCIT_C61812 type Class @default.
- NCIT_C61812 isDefinedBy ncit.owl @default.
- NCIT_C61812 label "Lithium Citrate" @default.
- NCIT_C61812 subClassOf NCIT_C1908 @default.
- NCIT_C61812 subClassOf NCIT_C1909 @default.
- NCIT_C61812 subClassOf NCIT_C29710 @default.
- NCIT_C61812 subClassOf NCIT_C61812 @default.
- NCIT_C61812 subClassOf NCIT_C78272 @default.