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- NCIT_C61854 IAO_0000115 "A synthetic mixed opioid agonist-antagonist with analgesic properties. Although its exact mechanism has not been fully delineated, it is hypothesized that upon administration, nalbuphine binds to kappa receptors in the central nervous system (CNS), thereby inhibiting the release of neurotransmitters that mediate pain, such as substance P. Additionally, nalbuphine exerts post-synaptic inhibitory effects on interneurons and output neurons of the spinothalamic tract, responsible for transporting nociceptive information. Compared to other opioid agents that stimulate mu receptors, nalbuphine antagonizes mu receptors, thereby potentially producing less intense respiratory depression." @default.
- NCIT_C61854 NCIT_A5 NCIT_C47629 @default.
- NCIT_C61854 NCIT_NHC0 "C61854" @default.
- NCIT_C61854 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61854 NCIT_P108 "Nalbuphine" @default.
- NCIT_C61854 NCIT_P207 "C0027348" @default.
- NCIT_C61854 NCIT_P210 "20594-83-6" @default.
- NCIT_C61854 NCIT_P319 "L2T84IQI2K" @default.
- NCIT_C61854 NCIT_P322 "FDA" @default.
- NCIT_C61854 NCIT_P329 "793677" @default.
- NCIT_C61854 NCIT_P330 "793677" @default.
- NCIT_C61854 NCIT_P350 "C21H27NO4" @default.
- NCIT_C61854 NCIT_P366 "Nalbuphine" @default.
- NCIT_C61854 NCIT_P368 "CHEBI:7454" @default.
- NCIT_C61854 NCIT_P399 "793677" @default.
- NCIT_C61854 normalizedInformationContent "100" @default.
- NCIT_C61854 referenceCount "1" @default.
- NCIT_C61854 hasExactSynonym "NALBUPHINE" @default.
- NCIT_C61854 hasExactSynonym "Nalbuphine" @default.
- NCIT_C61854 inSubset NCIT_C176424 @default.
- NCIT_C61854 inSubset NCIT_C63923 @default.
- NCIT_C61854 type Class @default.
- NCIT_C61854 isDefinedBy ncit.owl @default.
- NCIT_C61854 label "Nalbuphine" @default.
- NCIT_C61854 subClassOf NCIT_C1506 @default.
- NCIT_C61854 subClassOf NCIT_C1908 @default.
- NCIT_C61854 subClassOf NCIT_C1909 @default.
- NCIT_C61854 subClassOf NCIT_C1913 @default.
- NCIT_C61854 subClassOf NCIT_C1916 @default.
- NCIT_C61854 subClassOf NCIT_C221 @default.
- NCIT_C61854 subClassOf NCIT_C61854 @default.
- NCIT_C61854 subClassOf NCIT_C67413 @default.
- NCIT_C61854 subClassOf NCIT_C718 @default.
- NCIT_C61854 subClassOf NCIT_C78272 @default.