Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C61894> ?p ?o ?g. }
Showing items 1 to 32 of
32
with 100 items per page.
- NCIT_C61894 IAO_0000115 "A mixture of the polypeptides polymyxins B1 and B2, both obtained from Bacillus polymyxa strains, with antimicrobial activity. Polymyxin B exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death." @default.
- NCIT_C61894 NCIT_A5 NCIT_C61895 @default.
- NCIT_C61894 NCIT_NHC0 "C61894" @default.
- NCIT_C61894 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61894 NCIT_P107 "Polymyxin B" @default.
- NCIT_C61894 NCIT_P108 "Polymyxin B" @default.
- NCIT_C61894 NCIT_P207 "C0032535" @default.
- NCIT_C61894 NCIT_P210 "1404-26-8" @default.
- NCIT_C61894 NCIT_P319 "J2VZ07J96K" @default.
- NCIT_C61894 NCIT_P322 "CTRP" @default.
- NCIT_C61894 NCIT_P322 "FDA" @default.
- NCIT_C61894 NCIT_P329 "780525" @default.
- NCIT_C61894 NCIT_P330 "780525" @default.
- NCIT_C61894 NCIT_P366 "Polymyxin_B" @default.
- NCIT_C61894 NCIT_P399 "780525" @default.
- NCIT_C61894 normalizedInformationContent "100" @default.
- NCIT_C61894 referenceCount "1" @default.
- NCIT_C61894 hasExactSynonym "POLYMYXIN B" @default.
- NCIT_C61894 hasExactSynonym "Polymyxin B" @default.
- NCIT_C61894 inSubset NCIT_C116977 @default.
- NCIT_C61894 inSubset NCIT_C116978 @default.
- NCIT_C61894 inSubset NCIT_C176424 @default.
- NCIT_C61894 inSubset NCIT_C63923 @default.
- NCIT_C61894 type Class @default.
- NCIT_C61894 isDefinedBy ncit.owl @default.
- NCIT_C61894 label "Polymyxin B" @default.
- NCIT_C61894 subClassOf NCIT_C1908 @default.
- NCIT_C61894 subClassOf NCIT_C1909 @default.
- NCIT_C61894 subClassOf NCIT_C254 @default.
- NCIT_C61894 subClassOf NCIT_C258 @default.
- NCIT_C61894 subClassOf NCIT_C61894 @default.
- NCIT_C61894 subClassOf NCIT_C78160 @default.