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- NCIT_C61898 IAO_0000115 "A polypeptide obtained from Bacillus polymyxa strains with antimicrobial activity. Polymyxin B2 exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B2 dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death." @default.
- NCIT_C61898 NCIT_A5 NCIT_C61899 @default.
- NCIT_C61898 NCIT_NHC0 "C61898" @default.
- NCIT_C61898 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61898 NCIT_P108 "Polymyxin B2" @default.
- NCIT_C61898 NCIT_P207 "C1882419" @default.
- NCIT_C61898 NCIT_P210 "34503-87-2" @default.
- NCIT_C61898 NCIT_P319 "99SJO09VH2" @default.
- NCIT_C61898 NCIT_P322 "FDA" @default.
- NCIT_C61898 NCIT_P350 "C55H96N16O13" @default.
- NCIT_C61898 NCIT_P366 "Polymyxin_B2" @default.
- NCIT_C61898 NCIT_P368 "CHEBI:59063" @default.
- NCIT_C61898 normalizedInformationContent "100" @default.
- NCIT_C61898 referenceCount "1" @default.
- NCIT_C61898 hasExactSynonym "POLYMYXIN B2" @default.
- NCIT_C61898 hasExactSynonym "Polymyxin B2" @default.
- NCIT_C61898 inSubset NCIT_C63923 @default.
- NCIT_C61898 type Class @default.
- NCIT_C61898 isDefinedBy ncit.owl @default.
- NCIT_C61898 label "Polymyxin B2" @default.
- NCIT_C61898 subClassOf NCIT_C1908 @default.
- NCIT_C61898 subClassOf NCIT_C1909 @default.
- NCIT_C61898 subClassOf NCIT_C254 @default.
- NCIT_C61898 subClassOf NCIT_C258 @default.
- NCIT_C61898 subClassOf NCIT_C61898 @default.
- NCIT_C61898 subClassOf NCIT_C78160 @default.