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- NCIT_C61929 IAO_0000115 "A phenethylamine derivative with tocolytic activity. Ritodrine binds to and activates beta-2 adrenergic receptors of myometrial cells in the uterus, which decreases the intensity and frequency of uterine contractions. Specifically, ritodrine probably activates adenyl cyclase, thereby increasing production of cyclic adenosine monophosphate (cAMP), which in turn enhances the efflux of calcium from vascular smooth muscle cells. A lack of intracellular calcium prevents uterine myometrial contractions. In addition, this agent may directly inactivate myosin light chain kinase, a critical enzyme necessary for the initiation of muscle contractions." @default.
- NCIT_C61929 NCIT_A5 NCIT_C47706 @default.
- NCIT_C61929 NCIT_NHC0 "C61929" @default.
- NCIT_C61929 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61929 NCIT_P108 "Ritodrine" @default.
- NCIT_C61929 NCIT_P207 "C0035661" @default.
- NCIT_C61929 NCIT_P210 "26652-09-5" @default.
- NCIT_C61929 NCIT_P319 "I0Q6O6740J" @default.
- NCIT_C61929 NCIT_P322 "FDA" @default.
- NCIT_C61929 NCIT_P350 "C17H21NO3" @default.
- NCIT_C61929 NCIT_P366 "Ritodrine" @default.
- NCIT_C61929 normalizedInformationContent "100" @default.
- NCIT_C61929 referenceCount "1" @default.
- NCIT_C61929 hasExactSynonym "RITODRINE" @default.
- NCIT_C61929 hasExactSynonym "Ritodrine" @default.
- NCIT_C61929 inSubset NCIT_C63923 @default.
- NCIT_C61929 type Class @default.
- NCIT_C61929 isDefinedBy ncit.owl @default.
- NCIT_C61929 label "Ritodrine" @default.
- NCIT_C61929 subClassOf NCIT_C1908 @default.
- NCIT_C61929 subClassOf NCIT_C1909 @default.
- NCIT_C61929 subClassOf NCIT_C29747 @default.
- NCIT_C61929 subClassOf NCIT_C48149 @default.
- NCIT_C61929 subClassOf NCIT_C61929 @default.
- NCIT_C61929 subClassOf NCIT_C78272 @default.
- NCIT_C61929 subClassOf NCIT_C87053 @default.