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- NCIT_C61940 IAO_0000115 "An orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection. In the smooth muscle of the pulmonary vasculature, the increase in cGMP results in smooth muscle relaxation, vasodilation of the pulmonary vascular bed, relieving pulmonary hypertension and increasing blood flow in the lungs. In addition, sildenafil may reduce airway inflammation and mucus production." @default.
- NCIT_C61940 NCIT_A5 NCIT_C26670 @default.
- NCIT_C61940 NCIT_A7 NCIT_C95469 @default.
- NCIT_C61940 NCIT_NHC0 "C61940" @default.
- NCIT_C61940 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61940 NCIT_P107 "Sildenafil" @default.
- NCIT_C61940 NCIT_P108 "Sildenafil" @default.
- NCIT_C61940 NCIT_P207 "C0529793" @default.
- NCIT_C61940 NCIT_P210 "139755-83-2" @default.
- NCIT_C61940 NCIT_P319 "3M7OB98Y7H" @default.
- NCIT_C61940 NCIT_P322 "CTRP" @default.
- NCIT_C61940 NCIT_P322 "FDA" @default.
- NCIT_C61940 NCIT_P325 "A drug used to treat erectile dysfunction. Sildenafil relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase inhibitor." @default.
- NCIT_C61940 NCIT_P350 "C22H30N6O4S" @default.
- NCIT_C61940 NCIT_P366 "Sildenafil" @default.
- NCIT_C61940 NCIT_P368 "CHEBI:9139" @default.
- NCIT_C61940 normalizedInformationContent "100" @default.
- NCIT_C61940 referenceCount "1" @default.
- NCIT_C61940 hasExactSynonym "SILDENAFIL" @default.
- NCIT_C61940 hasExactSynonym "Sildenafil" @default.
- NCIT_C61940 hasExactSynonym "sildenafil" @default.
- NCIT_C61940 inSubset NCIT_C116977 @default.
- NCIT_C61940 inSubset NCIT_C116978 @default.
- NCIT_C61940 inSubset NCIT_C173381 @default.
- NCIT_C61940 inSubset NCIT_C173383 @default.
- NCIT_C61940 inSubset NCIT_C63923 @default.
- NCIT_C61940 type Class @default.
- NCIT_C61940 isDefinedBy ncit.owl @default.
- NCIT_C61940 label "Sildenafil" @default.
- NCIT_C61940 subClassOf NCIT_C1908 @default.
- NCIT_C61940 subClassOf NCIT_C1909 @default.
- NCIT_C61940 subClassOf NCIT_C2127 @default.
- NCIT_C61940 subClassOf NCIT_C29707 @default.
- NCIT_C61940 subClassOf NCIT_C471 @default.
- NCIT_C61940 subClassOf NCIT_C61940 @default.
- NCIT_C61940 subClassOf NCIT_C744 @default.
- NCIT_C61940 subClassOf NCIT_C78274 @default.