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- NCIT_C61965 IAO_0000115 "An ethanolamine derivative with bronchodilating and tocolytic activities. Terbutaline selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic AMP (cAMP) production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids in the relaxation of airway muscles. Terbutaline also increases mucociliary clearance and reduces release of inflammatory cell mediators." @default.
- NCIT_C61965 NCIT_A5 NCIT_C47748 @default.
- NCIT_C61965 NCIT_NHC0 "C61965" @default.
- NCIT_C61965 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61965 NCIT_P108 "Terbutaline" @default.
- NCIT_C61965 NCIT_P207 "C0039542" @default.
- NCIT_C61965 NCIT_P210 "23031-25-6" @default.
- NCIT_C61965 NCIT_P319 "N8ONU3L3PG" @default.
- NCIT_C61965 NCIT_P322 "FDA" @default.
- NCIT_C61965 NCIT_P350 "C12H19NO3" @default.
- NCIT_C61965 NCIT_P366 "Terbutaline" @default.
- NCIT_C61965 NCIT_P368 "CHEBI:9449" @default.
- NCIT_C61965 normalizedInformationContent "100" @default.
- NCIT_C61965 referenceCount "1" @default.
- NCIT_C61965 hasExactSynonym "TERBUTALINE" @default.
- NCIT_C61965 hasExactSynonym "Terbutaline" @default.
- NCIT_C61965 inSubset NCIT_C63923 @default.
- NCIT_C61965 type Class @default.
- NCIT_C61965 isDefinedBy ncit.owl @default.
- NCIT_C61965 label "Terbutaline" @default.
- NCIT_C61965 subClassOf NCIT_C1908 @default.
- NCIT_C61965 subClassOf NCIT_C1909 @default.
- NCIT_C61965 subClassOf NCIT_C29712 @default.
- NCIT_C61965 subClassOf NCIT_C29747 @default.
- NCIT_C61965 subClassOf NCIT_C319 @default.
- NCIT_C61965 subClassOf NCIT_C48149 @default.
- NCIT_C61965 subClassOf NCIT_C61965 @default.
- NCIT_C61965 subClassOf NCIT_C78272 @default.
- NCIT_C61965 subClassOf NCIT_C78273 @default.
- NCIT_C61965 subClassOf NCIT_C87053 @default.