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- NCIT_C61970 IAO_0000115 "The anhydrous salt form of thioguanine, a synthetic guanosine analogue antimetabolite, with antineoplastic activity. Thioguanine is phosphorylated by hypoxanthine-guanine phosphoribosyltransferase to 6-thioguanylic acid (TGMP) and upon conversion to thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP), this agent is incorporated into DNA and RNA, resulting in inhibition of DNA and RNA synthesis and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine ribonulceotide synthesis." @default.
- NCIT_C61970 NCIT_A32 NCIT_C1909 @default.
- NCIT_C61970 NCIT_NHC0 "C61970" @default.
- NCIT_C61970 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61970 NCIT_P108 "Thioguanine Anhydrous" @default.
- NCIT_C61970 NCIT_P207 "C1883309" @default.
- NCIT_C61970 NCIT_P210 "154-42-7" @default.
- NCIT_C61970 NCIT_P319 "WIX31ZPX66" @default.
- NCIT_C61970 NCIT_P322 "FDA" @default.
- NCIT_C61970 NCIT_P322 "GDC" @default.
- NCIT_C61970 NCIT_P350 "C5H5N5S" @default.
- NCIT_C61970 NCIT_P366 "Thioguanine_Anhydrous" @default.
- NCIT_C61970 NCIT_P375 "Thioguanine Anhydrous" @default.
- NCIT_C61970 normalizedInformationContent "100" @default.
- NCIT_C61970 referenceCount "1" @default.
- NCIT_C61970 hasExactSynonym "THIOGUANINE ANHYDROUS" @default.
- NCIT_C61970 hasExactSynonym "Thioguanine Anhydrous" @default.
- NCIT_C61970 inSubset NCIT_C128784 @default.
- NCIT_C61970 inSubset NCIT_C157711 @default.
- NCIT_C61970 inSubset NCIT_C157712 @default.
- NCIT_C61970 inSubset NCIT_C177537 @default.
- NCIT_C61970 inSubset NCIT_C63923 @default.
- NCIT_C61970 type Class @default.
- NCIT_C61970 isDefinedBy ncit.owl @default.
- NCIT_C61970 label "Thioguanine Anhydrous" @default.
- NCIT_C61970 subClassOf NCIT_C1556 @default.
- NCIT_C61970 subClassOf NCIT_C186664 @default.
- NCIT_C61970 subClassOf NCIT_C1908 @default.
- NCIT_C61970 subClassOf NCIT_C1909 @default.
- NCIT_C61970 subClassOf NCIT_C2254 @default.
- NCIT_C61970 subClassOf NCIT_C272 @default.
- NCIT_C61970 subClassOf NCIT_C274 @default.
- NCIT_C61970 subClassOf NCIT_C471 @default.
- NCIT_C61970 subClassOf NCIT_C61970 @default.