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- NCIT_C61973 IAO_0000115 "The disodium salt form of tiludronate, a first-generation, non-nitrogenous bisphosphonate analogue of endogenous pyrophosphate. Tiludronate adsorbs to hydroxyapatite cells, and although the exact mechanism through which this bisphosphonate exerts its effect has yet to be fully elucidated, tiludronate appears to inhibit protein-tyrosine-phosphatase (PTP) in osteoclasts, thereby disrupting the cytoskeletal ring structure and suppressing the bone resorbing activity of osteoclasts. In addition, tiludronate appears to inhibit the vacuolar-type proton ATPase (V-ATPase) in osteoclasts. Altogether, this may reduce the number of osteoclasts, inhibit abnormal bone resorption and reduce bone turnover." @default.
- NCIT_C61973 NCIT_NHC0 "C61973" @default.
- NCIT_C61973 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61973 NCIT_P108 "Tiludronate Disodium" @default.
- NCIT_C61973 NCIT_P207 "C0286030" @default.
- NCIT_C61973 NCIT_P210 "149845-07-8" @default.
- NCIT_C61973 NCIT_P319 "BH6M93CIA0" @default.
- NCIT_C61973 NCIT_P322 "FDA" @default.
- NCIT_C61973 NCIT_P350 "C7H7ClO6P2S.2Na" @default.
- NCIT_C61973 NCIT_P366 "Tiludronate_Disodium" @default.
- NCIT_C61973 normalizedInformationContent "100" @default.
- NCIT_C61973 referenceCount "1" @default.
- NCIT_C61973 hasExactSynonym "Skelid" @default.
- NCIT_C61973 hasExactSynonym "TILUDRONATE DISODIUM" @default.
- NCIT_C61973 hasExactSynonym "Tiludronate Disodium" @default.
- NCIT_C61973 inSubset NCIT_C63923 @default.
- NCIT_C61973 type Class @default.
- NCIT_C61973 isDefinedBy ncit.owl @default.
- NCIT_C61973 label "Tiludronate Disodium" @default.
- NCIT_C61973 subClassOf NCIT_C1908 @default.
- NCIT_C61973 subClassOf NCIT_C1909 @default.
- NCIT_C61973 subClassOf NCIT_C1913 @default.
- NCIT_C61973 subClassOf NCIT_C443 @default.
- NCIT_C61973 subClassOf NCIT_C61973 @default.
- NCIT_C61973 subClassOf NCIT_C67439 @default.
- NCIT_C61973 subClassOf NCIT_C718 @default.
- NCIT_C61973 subClassOf NCIT_C78281 @default.