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- NCIT_C61978 IAO_0000115 "A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C61978 NCIT_NHC0 "C61978" @default.
- NCIT_C61978 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61978 NCIT_P108 "Trandolapril" @default.
- NCIT_C61978 NCIT_P207 "C0076891" @default.
- NCIT_C61978 NCIT_P210 "87679-37-6" @default.
- NCIT_C61978 NCIT_P319 "1T0N3G9CRC" @default.
- NCIT_C61978 NCIT_P322 "FDA" @default.
- NCIT_C61978 NCIT_P350 "C24H34N2O5" @default.
- NCIT_C61978 NCIT_P366 "Trandolapril" @default.
- NCIT_C61978 normalizedInformationContent "100" @default.
- NCIT_C61978 referenceCount "1" @default.
- NCIT_C61978 hasExactSynonym "Mavik" @default.
- NCIT_C61978 hasExactSynonym "TRANDOLAPRIL" @default.
- NCIT_C61978 hasExactSynonym "Trandolapril" @default.
- NCIT_C61978 inSubset NCIT_C63923 @default.
- NCIT_C61978 type Class @default.
- NCIT_C61978 isDefinedBy ncit.owl @default.
- NCIT_C61978 label "Trandolapril" @default.
- NCIT_C61978 subClassOf NCIT_C1908 @default.
- NCIT_C61978 subClassOf NCIT_C1909 @default.
- NCIT_C61978 subClassOf NCIT_C247 @default.
- NCIT_C61978 subClassOf NCIT_C270 @default.
- NCIT_C61978 subClassOf NCIT_C471 @default.
- NCIT_C61978 subClassOf NCIT_C61978 @default.
- NCIT_C61978 subClassOf NCIT_C78274 @default.
- NCIT_C61978 subClassOf NCIT_C783 @default.