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- NCIT_C61979 IAO_0000115 "An orally bioavailable, nonselective, irreversible, non-hydrazine inhibitor of both monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1/BHC110), with antidepressant and anxiolytic activities, and potential antineoplastic activities. Upon oral administration, tranylcypromine exerts its antidepressant and anxiolytic effects through the inhibition of MAO, an enzyme that catalyzes the breakdown of the monoamine neurotransmitters serotonin, norepinephrine, epinephrine and dopamine. This increases the concentrations and activity of these neurotransmitters. Tranylcypromine exerts its antineoplastic effect through the inhibition of LSD1. Inhibition of LSD1 prevents the transcription of LSD1 target genes. LSD1, a flavin-dependent monoamine oxidoreductase and a histone demethylase, is upregulated in a variety of cancers and plays a key role in tumor cell proliferation, migration, and invasion." @default.
- NCIT_C61979 NCIT_A5 NCIT_C61980 @default.
- NCIT_C61979 NCIT_NHC0 "C61979" @default.
- NCIT_C61979 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C61979 NCIT_P107 "Tranylcypromine" @default.
- NCIT_C61979 NCIT_P108 "Tranylcypromine" @default.
- NCIT_C61979 NCIT_P175 "80664" @default.
- NCIT_C61979 NCIT_P207 "C0040778" @default.
- NCIT_C61979 NCIT_P210 "155-09-9" @default.
- NCIT_C61979 NCIT_P210 "95-62-5" @default.
- NCIT_C61979 NCIT_P319 "3E3V44J4Z9" @default.
- NCIT_C61979 NCIT_P322 "CTRP" @default.
- NCIT_C61979 NCIT_P322 "FDA" @default.
- NCIT_C61979 NCIT_P350 "C9H11N" @default.
- NCIT_C61979 NCIT_P366 "Tranylcypromine" @default.
- NCIT_C61979 NCIT_P368 "CHEBI:9652" @default.
- NCIT_C61979 NCIT_P399 "812069" @default.
- NCIT_C61979 normalizedInformationContent "100" @default.
- NCIT_C61979 referenceCount "1" @default.
- NCIT_C61979 hasExactSynonym "SKF 385" @default.
- NCIT_C61979 hasExactSynonym "TRANYLCYPROMINE" @default.
- NCIT_C61979 hasExactSynonym "Tranylcypromine" @default.
- NCIT_C61979 inSubset NCIT_C116977 @default.
- NCIT_C61979 inSubset NCIT_C116978 @default.
- NCIT_C61979 inSubset NCIT_C63923 @default.
- NCIT_C61979 type Class @default.
- NCIT_C61979 isDefinedBy ncit.owl @default.
- NCIT_C61979 label "Tranylcypromine" @default.
- NCIT_C61979 subClassOf NCIT_C1908 @default.
- NCIT_C61979 subClassOf NCIT_C1909 @default.
- NCIT_C61979 subClassOf NCIT_C471 @default.
- NCIT_C61979 subClassOf NCIT_C61979 @default.
- NCIT_C61979 subClassOf NCIT_C667 @default.