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- NCIT_C620 IAO_0000115 "A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation." @default.
- NCIT_C620 NCIT_A32 NCIT_C1909 @default.
- NCIT_C620 NCIT_A7 NCIT_C54701 @default.
- NCIT_C620 NCIT_NHC0 "C620" @default.
- NCIT_C620 NCIT_P106 "Organic Chemical" @default.
- NCIT_C620 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C620 NCIT_P107 "Lovastatin" @default.
- NCIT_C620 NCIT_P108 "Lovastatin" @default.
- NCIT_C620 NCIT_P175 "633781" @default.
- NCIT_C620 NCIT_P207 "C0024027" @default.
- NCIT_C620 NCIT_P210 "75330-75-5" @default.
- NCIT_C620 NCIT_P302 "Atherosclerosis; Coronary heart disease, prevention; Hypercholesterolemia" @default.
- NCIT_C620 NCIT_P319 "9LHU78OQFD" @default.
- NCIT_C620 NCIT_P322 "CTRP" @default.
- NCIT_C620 NCIT_P322 "FDA" @default.
- NCIT_C620 NCIT_P322 "GDC" @default.
- NCIT_C620 NCIT_P325 "A drug used to lower the amount of cholesterol in the blood. It is also being studied in the prevention and treatment of some types of cancer. Lovastatin is a type of HMG-CoA reductase inhibitor (statin)." @default.
- NCIT_C620 NCIT_P329 "41658" @default.
- NCIT_C620 NCIT_P330 "41658" @default.
- NCIT_C620 NCIT_P350 "C24H36O5" @default.
- NCIT_C620 NCIT_P366 "Lovastatin" @default.
- NCIT_C620 NCIT_P368 "CHEBI:40303" @default.
- NCIT_C620 NCIT_P375 "Lovastatin" @default.
- NCIT_C620 NCIT_P399 "41658" @default.
- NCIT_C620 NCIT_R122 NCIT_C16484 @default.
- NCIT_C620 NCIT_R122 NCIT_C16486 @default.
- NCIT_C620 NCIT_R122 NCIT_C16554 @default.
- NCIT_C620 NCIT_R122 NCIT_C16865 @default.
- NCIT_C620 NCIT_R122 NCIT_C16946 @default.
- NCIT_C620 NCIT_R122 NCIT_C17021 @default.
- NCIT_C620 NCIT_R122 NCIT_C17573 @default.
- NCIT_C620 NCIT_R122 NCIT_C20027 @default.
- NCIT_C620 NCIT_R122 NCIT_C26548 @default.
- NCIT_C620 NCIT_R122 NCIT_C28459 @default.
- NCIT_C620 NCIT_R122 NCIT_C45999 @default.
- NCIT_C620 NCIT_R122 NCIT_C46000 @default.
- NCIT_C620 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C620 referenceCount "2" @default.
- NCIT_C620 hasExactSynonym "(2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester" @default.
- NCIT_C620 hasExactSynonym "LOVASTATIN" @default.
- NCIT_C620 hasExactSynonym "Lovastatin Sodium" @default.
- NCIT_C620 hasExactSynonym "Lovastatin" @default.
- NCIT_C620 hasExactSynonym "Mevacor" @default.
- NCIT_C620 hasExactSynonym "Mevinolin" @default.
- NCIT_C620 hasExactSynonym "Monacolin K" @default.
- NCIT_C620 hasExactSynonym "lovastatin" @default.
- NCIT_C620 inSubset NCIT_C116977 @default.
- NCIT_C620 inSubset NCIT_C116978 @default.
- NCIT_C620 inSubset NCIT_C128784 @default.
- NCIT_C620 inSubset NCIT_C157711 @default.
- NCIT_C620 inSubset NCIT_C157712 @default.
- NCIT_C620 inSubset NCIT_C176424 @default.
- NCIT_C620 inSubset NCIT_C177537 @default.
- NCIT_C620 inSubset NCIT_C63923 @default.
- NCIT_C620 type Class @default.
- NCIT_C620 isDefinedBy ncit.owl @default.
- NCIT_C620 label "Lovastatin" @default.
- NCIT_C620 subClassOf B365fcbce08051f59c273263c2a328bc7 @default.
- NCIT_C620 subClassOf B5132648770b541420d2b4985b3c4bc46 @default.
- NCIT_C620 subClassOf B8e248b2d19a0271fd685bb02912d333e @default.
- NCIT_C620 subClassOf B94e281e0f0b77b4ab8416473c32283f2 @default.
- NCIT_C620 subClassOf B97938f372df9ab6be6f63678bc9dbdea @default.
- NCIT_C620 subClassOf Bcccd135a43abb7dcf99a36cef5db76f0 @default.
- NCIT_C620 subClassOf NCIT_C1655 @default.
- NCIT_C620 subClassOf NCIT_C1908 @default.
- NCIT_C620 subClassOf NCIT_C1909 @default.
- NCIT_C620 subClassOf NCIT_C1913 @default.
- NCIT_C620 subClassOf NCIT_C1915 @default.
- NCIT_C620 subClassOf NCIT_C1933 @default.
- NCIT_C620 subClassOf NCIT_C29703 @default.
- NCIT_C620 subClassOf NCIT_C471 @default.
- NCIT_C620 subClassOf NCIT_C54679 @default.
- NCIT_C620 subClassOf NCIT_C552 @default.
- NCIT_C620 subClassOf NCIT_C553 @default.
- NCIT_C620 subClassOf NCIT_C620 @default.
- NCIT_C620 subClassOf NCIT_C718 @default.
- NCIT_C620 subClassOf NCIT_C78276 @default.