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- NCIT_C62002 IAO_0000115 "An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors." @default.
- NCIT_C62002 NCIT_A5 NCIT_C236 @default.
- NCIT_C62002 NCIT_NHC0 "C62002" @default.
- NCIT_C62002 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62002 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62002 NCIT_P108 "Amiodarone" @default.
- NCIT_C62002 NCIT_P207 "C0002598" @default.
- NCIT_C62002 NCIT_P210 "1951-25-3" @default.
- NCIT_C62002 NCIT_P319 "N3RQ532IUT" @default.
- NCIT_C62002 NCIT_P322 "FDA" @default.
- NCIT_C62002 NCIT_P350 "C25H29I2NO3" @default.
- NCIT_C62002 NCIT_P366 "Amiodarone_Base" @default.
- NCIT_C62002 NCIT_P368 "CHEBI:2663" @default.
- NCIT_C62002 NCIT_R122 NCIT_C16484 @default.
- NCIT_C62002 NCIT_R122 NCIT_C16486 @default.
- NCIT_C62002 NCIT_R122 NCIT_C16554 @default.
- NCIT_C62002 NCIT_R122 NCIT_C16865 @default.
- NCIT_C62002 NCIT_R122 NCIT_C16946 @default.
- NCIT_C62002 NCIT_R122 NCIT_C17021 @default.
- NCIT_C62002 NCIT_R122 NCIT_C17573 @default.
- NCIT_C62002 NCIT_R122 NCIT_C20027 @default.
- NCIT_C62002 NCIT_R122 NCIT_C26548 @default.
- NCIT_C62002 NCIT_R122 NCIT_C28459 @default.
- NCIT_C62002 normalizedInformationContent "100" @default.
- NCIT_C62002 referenceCount "1" @default.
- NCIT_C62002 hasExactSynonym "AMIODARONE" @default.
- NCIT_C62002 hasExactSynonym "Amiodarone" @default.
- NCIT_C62002 inSubset NCIT_C173381 @default.
- NCIT_C62002 inSubset NCIT_C173383 @default.
- NCIT_C62002 inSubset NCIT_C63923 @default.
- NCIT_C62002 type Class @default.
- NCIT_C62002 isDefinedBy ncit.owl @default.
- NCIT_C62002 label "Amiodarone" @default.
- NCIT_C62002 subClassOf B0c14da7b510ba96e1a62179de3f119c6 @default.
- NCIT_C62002 subClassOf Bcca0316b4f145d02b737cd6141215c18 @default.
- NCIT_C62002 subClassOf NCIT_C1908 @default.
- NCIT_C62002 subClassOf NCIT_C1909 @default.
- NCIT_C62002 subClassOf NCIT_C47793 @default.
- NCIT_C62002 subClassOf NCIT_C62002 @default.
- NCIT_C62002 subClassOf NCIT_C78274 @default.
- NCIT_C62002 subClassOf NCIT_C93038 @default.