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- NCIT_C62010 IAO_0000115 "A semisynthetic, ergot alkaloid with antiparkinson and lactation inhibitory activities. Bromocriptine selectively binds to and activates the postsynaptic dopamine D2-like receptors in the corpus striatum of the central nervous system (CNS). D2-like receptors are coupled to inhibitory G-proteins, which inhibit adenylyl cyclase, thereby preventing signal transduction mediated via cAMP and leading to an inhibitory effect on neurotransmission. This improves Parkinson symptoms, such as dyskinesia. Bromocriptine also has an inhibitory effect on the anterior pituitary gland, which results in blockage of prolactin secretion, thereby suppressing lactation." @default.
- NCIT_C62010 NCIT_A5 NCIT_C317 @default.
- NCIT_C62010 NCIT_NHC0 "C62010" @default.
- NCIT_C62010 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62010 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62010 NCIT_P108 "Bromocriptine" @default.
- NCIT_C62010 NCIT_P207 "C0006230" @default.
- NCIT_C62010 NCIT_P210 "25614-03-3" @default.
- NCIT_C62010 NCIT_P319 "3A64E3G5ZO" @default.
- NCIT_C62010 NCIT_P322 "FDA" @default.
- NCIT_C62010 NCIT_P350 "C32H40BrN5O5" @default.
- NCIT_C62010 NCIT_P366 "Bromocriptine_Base" @default.
- NCIT_C62010 NCIT_P368 "CHEBI:3181" @default.
- NCIT_C62010 normalizedInformationContent "100" @default.
- NCIT_C62010 referenceCount "1" @default.
- NCIT_C62010 hasExactSynonym "2-Bromo-alpha-ergocryptine" @default.
- NCIT_C62010 hasExactSynonym "BROMOCRIPTINE" @default.
- NCIT_C62010 hasExactSynonym "Bromocriptine" @default.
- NCIT_C62010 hasExactSynonym "Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'alpha)-" @default.
- NCIT_C62010 inSubset NCIT_C63923 @default.
- NCIT_C62010 type Class @default.
- NCIT_C62010 isDefinedBy ncit.owl @default.
- NCIT_C62010 label "Bromocriptine" @default.
- NCIT_C62010 subClassOf NCIT_C1509 @default.
- NCIT_C62010 subClassOf NCIT_C1908 @default.
- NCIT_C62010 subClassOf NCIT_C1909 @default.
- NCIT_C62010 subClassOf NCIT_C26170 @default.
- NCIT_C62010 subClassOf NCIT_C62010 @default.
- NCIT_C62010 subClassOf NCIT_C66884 @default.
- NCIT_C62010 subClassOf NCIT_C78272 @default.