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- NCIT_C62021 IAO_0000115 "A semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.
- NCIT_C62021 NCIT_A5 NCIT_C358 @default.
- NCIT_C62021 NCIT_NHC0 "C62021" @default.
- NCIT_C62021 NCIT_P106 "Antibiotic" @default.
- NCIT_C62021 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62021 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62021 NCIT_P108 "Cephalothin" @default.
- NCIT_C62021 NCIT_P207 "C0007735" @default.
- NCIT_C62021 NCIT_P210 "153-61-7" @default.
- NCIT_C62021 NCIT_P319 "R72LW146E6" @default.
- NCIT_C62021 NCIT_P322 "FDA" @default.
- NCIT_C62021 NCIT_P350 "C16H16N2O6S2" @default.
- NCIT_C62021 NCIT_P366 "Cephalothin_Base" @default.
- NCIT_C62021 NCIT_P368 "CHEBI:124991" @default.
- NCIT_C62021 normalizedInformationContent "100" @default.
- NCIT_C62021 referenceCount "1" @default.
- NCIT_C62021 hasExactSynonym "CEPHALOTHIN" @default.
- NCIT_C62021 hasExactSynonym "Cephalothin" @default.
- NCIT_C62021 inSubset NCIT_C63923 @default.
- NCIT_C62021 type Class @default.
- NCIT_C62021 isDefinedBy ncit.owl @default.
- NCIT_C62021 label "Cephalothin" @default.
- NCIT_C62021 subClassOf NCIT_C1908 @default.
- NCIT_C62021 subClassOf NCIT_C1909 @default.
- NCIT_C62021 subClassOf NCIT_C254 @default.
- NCIT_C62021 subClassOf NCIT_C258 @default.
- NCIT_C62021 subClassOf NCIT_C260 @default.
- NCIT_C62021 subClassOf NCIT_C357 @default.
- NCIT_C62021 subClassOf NCIT_C62021 @default.