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- NCIT_C62027 IAO_0000115 "A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C62027 NCIT_A5 NCIT_C468 @default.
- NCIT_C62027 NCIT_NHC0 "C62027" @default.
- NCIT_C62027 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C62027 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62027 NCIT_P108 "Enalapril" @default.
- NCIT_C62027 NCIT_P207 "C0014025" @default.
- NCIT_C62027 NCIT_P210 "75847-73-3" @default.
- NCIT_C62027 NCIT_P319 "69PN84IO1A" @default.
- NCIT_C62027 NCIT_P322 "FDA" @default.
- NCIT_C62027 NCIT_P325 "An antihypertensive agent that can also be used to slow or prevent the progression of heart disease in people with childhood cancer treated with drugs that may be harmful to the heart." @default.
- NCIT_C62027 NCIT_P350 "C20H28N2O5" @default.
- NCIT_C62027 NCIT_P366 "Enalapril_Base" @default.
- NCIT_C62027 NCIT_P368 "CHEBI:4784" @default.
- NCIT_C62027 NCIT_R122 NCIT_C16484 @default.
- NCIT_C62027 NCIT_R122 NCIT_C16486 @default.
- NCIT_C62027 NCIT_R122 NCIT_C16554 @default.
- NCIT_C62027 NCIT_R122 NCIT_C16865 @default.
- NCIT_C62027 NCIT_R122 NCIT_C16946 @default.
- NCIT_C62027 NCIT_R122 NCIT_C17021 @default.
- NCIT_C62027 NCIT_R122 NCIT_C17573 @default.
- NCIT_C62027 NCIT_R122 NCIT_C20027 @default.
- NCIT_C62027 NCIT_R122 NCIT_C26548 @default.
- NCIT_C62027 NCIT_R122 NCIT_C28459 @default.
- NCIT_C62027 normalizedInformationContent "100" @default.
- NCIT_C62027 referenceCount "1" @default.
- NCIT_C62027 hasExactSynonym "ENALAPRIL" @default.
- NCIT_C62027 hasExactSynonym "Enalapril" @default.
- NCIT_C62027 hasExactSynonym "enalapril" @default.
- NCIT_C62027 inSubset NCIT_C173381 @default.
- NCIT_C62027 inSubset NCIT_C173383 @default.
- NCIT_C62027 inSubset NCIT_C63923 @default.
- NCIT_C62027 type Class @default.
- NCIT_C62027 isDefinedBy ncit.owl @default.
- NCIT_C62027 label "Enalapril" @default.
- NCIT_C62027 subClassOf B44e1f1276b85f565dfdd7bea90fcf700 @default.
- NCIT_C62027 subClassOf B8e3bdcdfbabd5305ce898516efc001a8 @default.
- NCIT_C62027 subClassOf NCIT_C1908 @default.
- NCIT_C62027 subClassOf NCIT_C1909 @default.
- NCIT_C62027 subClassOf NCIT_C247 @default.
- NCIT_C62027 subClassOf NCIT_C270 @default.
- NCIT_C62027 subClassOf NCIT_C471 @default.
- NCIT_C62027 subClassOf NCIT_C62027 @default.
- NCIT_C62027 subClassOf NCIT_C78274 @default.
- NCIT_C62027 subClassOf NCIT_C783 @default.