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- NCIT_C62030 IAO_0000115 "A member of the benzodiazepines and a long-acting depressor of the central nervous system (CNS) with sedative and hypnotic effects. Flurazepam binds to a specific site on the benzodiazepine-gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability. By modulating binding of the GABA inhibitory neurotransmitter to GABA-A receptors in the ascending reticular activating system, flurazepam blocks arousal of the cortical and limbic system, thereby exerting its sedative and hypnotic effect." @default.
- NCIT_C62030 NCIT_A5 NCIT_C29060 @default.
- NCIT_C62030 NCIT_A5 NCIT_C98134 @default.
- NCIT_C62030 NCIT_NHC0 "C62030" @default.
- NCIT_C62030 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62030 NCIT_P108 "Flurazepam" @default.
- NCIT_C62030 NCIT_P207 "C0016375" @default.
- NCIT_C62030 NCIT_P210 "17617-23-1" @default.
- NCIT_C62030 NCIT_P319 "IHP475989U" @default.
- NCIT_C62030 NCIT_P322 "FDA" @default.
- NCIT_C62030 NCIT_P350 "C21H23ClFN3O" @default.
- NCIT_C62030 NCIT_P366 "Flurazepam_Base" @default.
- NCIT_C62030 normalizedInformationContent "100" @default.
- NCIT_C62030 referenceCount "1" @default.
- NCIT_C62030 hasExactSynonym "7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one" @default.
- NCIT_C62030 hasExactSynonym "FLURAZEPAM" @default.
- NCIT_C62030 hasExactSynonym "Flurazepam" @default.
- NCIT_C62030 hasExactSynonym "Ro-5-6901/3" @default.
- NCIT_C62030 inSubset NCIT_C63923 @default.
- NCIT_C62030 type Class @default.
- NCIT_C62030 isDefinedBy ncit.owl @default.
- NCIT_C62030 label "Flurazepam" @default.
- NCIT_C62030 subClassOf NCIT_C1012 @default.
- NCIT_C62030 subClassOf NCIT_C1908 @default.
- NCIT_C62030 subClassOf NCIT_C1909 @default.
- NCIT_C62030 subClassOf NCIT_C28197 @default.
- NCIT_C62030 subClassOf NCIT_C29756 @default.
- NCIT_C62030 subClassOf NCIT_C62030 @default.
- NCIT_C62030 subClassOf NCIT_C78272 @default.