Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C62034> ?p ?o ?g. }
Showing items 1 to 40 of
40
with 100 items per page.
- NCIT_C62034 IAO_0000115 "The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons." @default.
- NCIT_C62034 NCIT_A5 NCIT_C436 @default.
- NCIT_C62034 NCIT_NHC0 "C62034" @default.
- NCIT_C62034 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62034 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62034 NCIT_P107 "Hydromorphone" @default.
- NCIT_C62034 NCIT_P108 "Hydromorphone" @default.
- NCIT_C62034 NCIT_P207 "C0012306" @default.
- NCIT_C62034 NCIT_P210 "466-99-9" @default.
- NCIT_C62034 NCIT_P319 "Q812464R06" @default.
- NCIT_C62034 NCIT_P322 "CTRP" @default.
- NCIT_C62034 NCIT_P322 "FDA" @default.
- NCIT_C62034 NCIT_P325 "A drug used to relieve pain." @default.
- NCIT_C62034 NCIT_P350 "C17H19NO3" @default.
- NCIT_C62034 NCIT_P366 "Hydromorphone_Base" @default.
- NCIT_C62034 NCIT_P368 "CHEBI:5790" @default.
- NCIT_C62034 normalizedInformationContent "100" @default.
- NCIT_C62034 referenceCount "1" @default.
- NCIT_C62034 hasExactSynonym "(-)-Hydromorphone" @default.
- NCIT_C62034 hasExactSynonym "Dihydromorphinone" @default.
- NCIT_C62034 hasExactSynonym "HYDROMORPHONE" @default.
- NCIT_C62034 hasExactSynonym "Hydromorphon" @default.
- NCIT_C62034 hasExactSynonym "Hydromorphone" @default.
- NCIT_C62034 hasExactSynonym "hydromorphone" @default.
- NCIT_C62034 inSubset NCIT_C116977 @default.
- NCIT_C62034 inSubset NCIT_C116978 @default.
- NCIT_C62034 inSubset NCIT_C63923 @default.
- NCIT_C62034 type Class @default.
- NCIT_C62034 isDefinedBy ncit.owl @default.
- NCIT_C62034 label "Hydromorphone" @default.
- NCIT_C62034 subClassOf NCIT_C1506 @default.
- NCIT_C62034 subClassOf NCIT_C1908 @default.
- NCIT_C62034 subClassOf NCIT_C1909 @default.
- NCIT_C62034 subClassOf NCIT_C1913 @default.
- NCIT_C62034 subClassOf NCIT_C1916 @default.
- NCIT_C62034 subClassOf NCIT_C221 @default.
- NCIT_C62034 subClassOf NCIT_C62034 @default.
- NCIT_C62034 subClassOf NCIT_C67413 @default.
- NCIT_C62034 subClassOf NCIT_C718 @default.
- NCIT_C62034 subClassOf NCIT_C78272 @default.