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Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C62040> ?p ?o ?g. }

• NCIT_C62040 IAO_0000115 "A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent." @default.
• NCIT_C62040 NCIT_A32 NCIT_C1909 @default.
• NCIT_C62040 NCIT_A5 NCIT_C1381 @default.
• NCIT_C62040 NCIT_A7 NCIT_C16516 @default.
• NCIT_C62040 NCIT_NHC0 "C62040" @default.
• NCIT_C62040 NCIT_P106 "Organic Chemical" @default.
• NCIT_C62040 NCIT_P106 "Pharmacologic Substance" @default.
• NCIT_C62040 NCIT_P107 "Irinotecan" @default.
• NCIT_C62040 NCIT_P108 "Irinotecan" @default.
• NCIT_C62040 NCIT_P175 "616348" @default.
• NCIT_C62040 NCIT_P175 "728073" @default.
• NCIT_C62040 NCIT_P207 "C0123931" @default.
• NCIT_C62040 NCIT_P210 "97682-44-5" @default.
• NCIT_C62040 NCIT_P319 "7673326042" @default.
• NCIT_C62040 NCIT_P322 "CTRP" @default.
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• NCIT_C62040 NCIT_P325 "The active ingredient in a drug used alone or with other drugs to treat colon cancer or rectal cancer that has spread to other parts of the body or has come back after treatment with fluorouracil. It is also being studied in the treatment of other types of cancer. Irinotecan blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog." @default.
• NCIT_C62040 NCIT_P350 "C33H38N4O6" @default.
• NCIT_C62040 NCIT_P366 "Irinotecan_Base" @default.
• NCIT_C62040 NCIT_P375 "Irinotecan" @default.
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• NCIT_C62040 NCIT_R146 NCIT_C20646 @default.
• NCIT_C62040 NCIT_R146 NCIT_C26548 @default.
• NCIT_C62040 normalizedInformationContent "85.460608731874885" @default.
• NCIT_C62040 referenceCount "9" @default.
• NCIT_C62040 hasExactSynonym "(+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione" @default.
• NCIT_C62040 hasExactSynonym "(+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate" @default.
• NCIT_C62040 hasExactSynonym "7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin" @default.
• NCIT_C62040 hasExactSynonym "IRINOTECAN" @default.
• NCIT_C62040 hasExactSynonym "Irinotecan" @default.
• NCIT_C62040 hasExactSynonym "[1,4'-bipiperidine]-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester" @default.
• NCIT_C62040 hasExactSynonym "irinotecan" @default.
• NCIT_C62040 inSubset NCIT_C116977 @default.
• NCIT_C62040 inSubset NCIT_C116978 @default.
• NCIT_C62040 inSubset NCIT_C128784 @default.
• NCIT_C62040 inSubset NCIT_C157711 @default.
• NCIT_C62040 inSubset NCIT_C157712 @default.
• NCIT_C62040 inSubset NCIT_C177537 @default.
• NCIT_C62040 inSubset NCIT_C63923 @default.
• NCIT_C62040 type Class @default.
• NCIT_C62040 isDefinedBy ncit.owl @default.
• NCIT_C62040 label "Irinotecan" @default.
• NCIT_C62040 subClassOf B0366d5fe876d7365c55dd1665ee2508d @default.
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