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- NCIT_C62042 IAO_0000115 "A synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression." @default.
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- NCIT_C62042 NCIT_A7 NCIT_C38910 @default.
- NCIT_C62042 NCIT_NHC0 "C62042" @default.
- NCIT_C62042 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C62042 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62042 NCIT_P107 "Leuprolide" @default.
- NCIT_C62042 NCIT_P108 "Leuprolide" @default.
- NCIT_C62042 NCIT_P175 "377526" @default.
- NCIT_C62042 NCIT_P207 "C0085272" @default.
- NCIT_C62042 NCIT_P210 "53714-56-0" @default.
- NCIT_C62042 NCIT_P319 "EFY6W0M8TG" @default.
- NCIT_C62042 NCIT_P322 "CTRP" @default.
- NCIT_C62042 NCIT_P322 "FDA" @default.
- NCIT_C62042 NCIT_P322 "GDC" @default.
- NCIT_C62042 NCIT_P322 "OORO" @default.
- NCIT_C62042 NCIT_P325 "The active ingredient in a drug used to treat symptoms of advanced prostate cancer. It is also used to treat early puberty in children and certain gynecologic conditions. It is being studied in the treatment of other conditions and types of cancer. Leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. It is a type of gonadotropin-releasing hormone analog." @default.
- NCIT_C62042 NCIT_P350 "C59H84N16O12" @default.
- NCIT_C62042 NCIT_P366 "Leuprolide_Base" @default.
- NCIT_C62042 NCIT_P368 "CHEBI:6427" @default.
- NCIT_C62042 NCIT_P375 "Leuprolide" @default.
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- NCIT_C62042 NCIT_R146 NCIT_C18239 @default.
- NCIT_C62042 NCIT_R146 NCIT_C20027 @default.
- NCIT_C62042 NCIT_R146 NCIT_C26548 @default.
- NCIT_C62042 NCIT_R146 NCIT_C38910 @default.
- NCIT_C62042 normalizedInformationContent "100" @default.
- NCIT_C62042 referenceCount "1" @default.
- NCIT_C62042 hasExactSynonym "6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig)" @default.
- NCIT_C62042 hasExactSynonym "6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig)" @default.
- NCIT_C62042 hasExactSynonym "LEUPROLIDE" @default.
- NCIT_C62042 hasExactSynonym "Leuprolide" @default.
- NCIT_C62042 hasExactSynonym "Leuprorelin" @default.
- NCIT_C62042 hasExactSynonym "leuprolide" @default.
- NCIT_C62042 inSubset NCIT_C116977 @default.
- NCIT_C62042 inSubset NCIT_C116978 @default.
- NCIT_C62042 inSubset NCIT_C128784 @default.
- NCIT_C62042 inSubset NCIT_C157711 @default.
- NCIT_C62042 inSubset NCIT_C157712 @default.
- NCIT_C62042 inSubset NCIT_C177537 @default.
- NCIT_C62042 inSubset NCIT_C192234 @default.
- NCIT_C62042 inSubset NCIT_C63923 @default.
- NCIT_C62042 type Class @default.
- NCIT_C62042 isDefinedBy ncit.owl @default.
- NCIT_C62042 label "Leuprolide" @default.
- NCIT_C62042 subClassOf B3deb7cddd899835feb064dc7c15cc19b @default.
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- NCIT_C62042 subClassOf NCIT_C147908 @default.
- NCIT_C62042 subClassOf NCIT_C1908 @default.
- NCIT_C62042 subClassOf NCIT_C1909 @default.
- NCIT_C62042 subClassOf NCIT_C1910 @default.
- NCIT_C62042 subClassOf NCIT_C548 @default.
- NCIT_C62042 subClassOf NCIT_C62042 @default.