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- NCIT_C62046 IAO_0000115 "A substituted benzamide and a derivative of para-aminobenzoic acid (PABA) that is structurally related to procainamide, with gastroprokinetic and antiemetic effects. Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation effect on gastrointestinal smooth muscle. This enhances the response of the gastrointestinal smooth muscle to cholinergic stimulation, thereby leading to an increase of gastric emptying into the intestines. Metoclopramide may also strengthen the lower esophagus sphincter, thereby preventing acid reflux. This agent antagonizes D2 dopamine receptors in chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting." @default.
- NCIT_C62046 NCIT_A5 NCIT_C649 @default.
- NCIT_C62046 NCIT_A7 NCIT_C17292 @default.
- NCIT_C62046 NCIT_NHC0 "C62046" @default.
- NCIT_C62046 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62046 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62046 NCIT_P107 "Metoclopramide" @default.
- NCIT_C62046 NCIT_P108 "Metoclopramide" @default.
- NCIT_C62046 NCIT_P207 "C0025853" @default.
- NCIT_C62046 NCIT_P210 "364-62-5" @default.
- NCIT_C62046 NCIT_P319 "L4YEB44I46" @default.
- NCIT_C62046 NCIT_P322 "CTRP" @default.
- NCIT_C62046 NCIT_P322 "FDA" @default.
- NCIT_C62046 NCIT_P325 "A drug that increases the motility (movements and contractions) of the stomach and upper intestine. It is used to treat certain stomach problems and nausea and vomiting caused by chemotherapy. It is a type of antiemetic and a type of motility agent." @default.
- NCIT_C62046 NCIT_P350 "C14H22ClN3O2" @default.
- NCIT_C62046 NCIT_P366 "Metoclopramide_Base" @default.
- NCIT_C62046 NCIT_P368 "CHEBI:107736" @default.
- NCIT_C62046 NCIT_R122 NCIT_C16484 @default.
- NCIT_C62046 NCIT_R122 NCIT_C16486 @default.
- NCIT_C62046 NCIT_R122 NCIT_C16554 @default.
- NCIT_C62046 NCIT_R122 NCIT_C16865 @default.
- NCIT_C62046 NCIT_R122 NCIT_C16946 @default.
- NCIT_C62046 NCIT_R122 NCIT_C17021 @default.
- NCIT_C62046 NCIT_R122 NCIT_C17287 @default.
- NCIT_C62046 NCIT_R122 NCIT_C20027 @default.
- NCIT_C62046 NCIT_R122 NCIT_C26548 @default.
- NCIT_C62046 NCIT_R122 NCIT_C28459 @default.
- NCIT_C62046 normalizedInformationContent "100" @default.
- NCIT_C62046 referenceCount "1" @default.
- NCIT_C62046 hasExactSynonym "METOCLOPRAMIDE" @default.
- NCIT_C62046 hasExactSynonym "Metoclopramide" @default.
- NCIT_C62046 hasExactSynonym "metoclopramide" @default.
- NCIT_C62046 inSubset NCIT_C116977 @default.
- NCIT_C62046 inSubset NCIT_C116978 @default.
- NCIT_C62046 inSubset NCIT_C63923 @default.
- NCIT_C62046 type Class @default.
- NCIT_C62046 isDefinedBy ncit.owl @default.
- NCIT_C62046 label "Metoclopramide" @default.
- NCIT_C62046 subClassOf B1783cf7c7dbae4933385364a81962c45 @default.
- NCIT_C62046 subClassOf B9cc6958ed64452c834d1cf7265741691 @default.
- NCIT_C62046 subClassOf NCIT_C1908 @default.
- NCIT_C62046 subClassOf NCIT_C1909 @default.
- NCIT_C62046 subClassOf NCIT_C267 @default.
- NCIT_C62046 subClassOf NCIT_C62046 @default.
- NCIT_C62046 subClassOf NCIT_C78272 @default.