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- NCIT_C62070 IAO_0000115 "A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)" @default.
- NCIT_C62070 NCIT_A5 NCIT_C29375 @default.
- NCIT_C62070 NCIT_A7 NCIT_C54701 @default.
- NCIT_C62070 NCIT_NHC0 "C62070" @default.
- NCIT_C62070 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62070 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62070 NCIT_P107 "Pravastatin" @default.
- NCIT_C62070 NCIT_P108 "Pravastatin" @default.
- NCIT_C62070 NCIT_P207 "C0085542" @default.
- NCIT_C62070 NCIT_P210 "81093-37-0" @default.
- NCIT_C62070 NCIT_P319 "KXO2KT9N0G" @default.
- NCIT_C62070 NCIT_P322 "CTRP" @default.
- NCIT_C62070 NCIT_P322 "FDA" @default.
- NCIT_C62070 NCIT_P325 "The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke and heart attack. It is also being studied in the treatment of cancer and other conditions. Pravastatin blocks an enzyme that helps make cholesterol in the body. It may also make tumor cells more sensitive to anticancer drugs. It is a type of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer." @default.
- NCIT_C62070 NCIT_P350 "C23H36O7" @default.
- NCIT_C62070 NCIT_P366 "Pravastatin_Base" @default.
- NCIT_C62070 NCIT_P368 "CHEBI:63618" @default.
- NCIT_C62070 normalizedInformationContent "100" @default.
- NCIT_C62070 referenceCount "1" @default.
- NCIT_C62070 hasExactSynonym "PRAVASTATIN" @default.
- NCIT_C62070 hasExactSynonym "Pravastatin" @default.
- NCIT_C62070 hasExactSynonym "[1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid" @default.
- NCIT_C62070 hasExactSynonym "pravastatin" @default.
- NCIT_C62070 inSubset NCIT_C116977 @default.
- NCIT_C62070 inSubset NCIT_C116978 @default.
- NCIT_C62070 inSubset NCIT_C63923 @default.
- NCIT_C62070 type Class @default.
- NCIT_C62070 isDefinedBy ncit.owl @default.
- NCIT_C62070 label "Pravastatin" @default.
- NCIT_C62070 subClassOf NCIT_C1655 @default.
- NCIT_C62070 subClassOf NCIT_C1908 @default.
- NCIT_C62070 subClassOf NCIT_C1909 @default.
- NCIT_C62070 subClassOf NCIT_C29703 @default.
- NCIT_C62070 subClassOf NCIT_C471 @default.
- NCIT_C62070 subClassOf NCIT_C62070 @default.
- NCIT_C62070 subClassOf NCIT_C78276 @default.