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- NCIT_C62072 IAO_0000115 "A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction." @default.
- NCIT_C62072 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62072 NCIT_A5 NCIT_C773 @default.
- NCIT_C62072 NCIT_NHC0 "C62072" @default.
- NCIT_C62072 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62072 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62072 NCIT_P107 "Procarbazine" @default.
- NCIT_C62072 NCIT_P108 "Procarbazine" @default.
- NCIT_C62072 NCIT_P207 "C0033223" @default.
- NCIT_C62072 NCIT_P210 "671-16-9" @default.
- NCIT_C62072 NCIT_P319 "35S93Y190K" @default.
- NCIT_C62072 NCIT_P322 "CTRP" @default.
- NCIT_C62072 NCIT_P322 "FDA" @default.
- NCIT_C62072 NCIT_P322 "GDC" @default.
- NCIT_C62072 NCIT_P322 "PCDC" @default.
- NCIT_C62072 NCIT_P325 "The active ingredient in a drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Procarbazine blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent." @default.
- NCIT_C62072 NCIT_P350 "C12H19N3O" @default.
- NCIT_C62072 NCIT_P366 "Procarbazine_Base" @default.
- NCIT_C62072 NCIT_P375 "Procarbazine" @default.
- NCIT_C62072 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C62072 referenceCount "3" @default.
- NCIT_C62072 hasExactSynonym "Benzethyzin" @default.
- NCIT_C62072 hasExactSynonym "Ibenzmethyzin" @default.
- NCIT_C62072 hasExactSynonym "N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide" @default.
- NCIT_C62072 hasExactSynonym "N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine" @default.
- NCIT_C62072 hasExactSynonym "N-Methylhydrazine" @default.
- NCIT_C62072 hasExactSynonym "N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide" @default.
- NCIT_C62072 hasExactSynonym "PROCARBAZINE" @default.
- NCIT_C62072 hasExactSynonym "Procarbazin" @default.
- NCIT_C62072 hasExactSynonym "Procarbazine" @default.
- NCIT_C62072 hasExactSynonym "p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide" @default.
- NCIT_C62072 hasExactSynonym "procarbazine" @default.
- NCIT_C62072 inSubset NCIT_C116977 @default.
- NCIT_C62072 inSubset NCIT_C116978 @default.
- NCIT_C62072 inSubset NCIT_C128784 @default.
- NCIT_C62072 inSubset NCIT_C157711 @default.
- NCIT_C62072 inSubset NCIT_C157712 @default.
- NCIT_C62072 inSubset NCIT_C177537 @default.
- NCIT_C62072 inSubset NCIT_C186327 @default.
- NCIT_C62072 inSubset NCIT_C186328 @default.
- NCIT_C62072 inSubset NCIT_C186341 @default.
- NCIT_C62072 inSubset NCIT_C63923 @default.
- NCIT_C62072 type Class @default.
- NCIT_C62072 isDefinedBy ncit.owl @default.
- NCIT_C62072 label "Procarbazine" @default.
- NCIT_C62072 subClassOf NCIT_C1590 @default.
- NCIT_C62072 subClassOf NCIT_C186664 @default.
- NCIT_C62072 subClassOf NCIT_C1908 @default.
- NCIT_C62072 subClassOf NCIT_C1909 @default.
- NCIT_C62072 subClassOf NCIT_C274 @default.
- NCIT_C62072 subClassOf NCIT_C2842 @default.
- NCIT_C62072 subClassOf NCIT_C62072 @default.
- NCIT_C62072 subClassOf NCIT_C902 @default.