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- NCIT_C62074 IAO_0000115 "A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels." @default.
- NCIT_C62074 NCIT_A5 NCIT_C29398 @default.
- NCIT_C62074 NCIT_NHC0 "C62074" @default.
- NCIT_C62074 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62074 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62074 NCIT_P108 "Quinapril" @default.
- NCIT_C62074 NCIT_P207 "C0072857" @default.
- NCIT_C62074 NCIT_P210 "85441-61-8" @default.
- NCIT_C62074 NCIT_P319 "RJ84Y44811" @default.
- NCIT_C62074 NCIT_P322 "FDA" @default.
- NCIT_C62074 NCIT_P350 "C25H30N2O5" @default.
- NCIT_C62074 NCIT_P366 "Quinapril_Base" @default.
- NCIT_C62074 NCIT_P368 "CHEBI:8713" @default.
- NCIT_C62074 normalizedInformationContent "100" @default.
- NCIT_C62074 referenceCount "1" @default.
- NCIT_C62074 hasExactSynonym "QUINAPRIL" @default.
- NCIT_C62074 hasExactSynonym "Quinapril" @default.
- NCIT_C62074 inSubset NCIT_C63923 @default.
- NCIT_C62074 type Class @default.
- NCIT_C62074 isDefinedBy ncit.owl @default.
- NCIT_C62074 label "Quinapril" @default.
- NCIT_C62074 subClassOf NCIT_C1908 @default.
- NCIT_C62074 subClassOf NCIT_C1909 @default.
- NCIT_C62074 subClassOf NCIT_C247 @default.
- NCIT_C62074 subClassOf NCIT_C270 @default.
- NCIT_C62074 subClassOf NCIT_C471 @default.
- NCIT_C62074 subClassOf NCIT_C62074 @default.
- NCIT_C62074 subClassOf NCIT_C78274 @default.
- NCIT_C62074 subClassOf NCIT_C783 @default.