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- NCIT_C62083 IAO_0000115 "A benzhydryl compound and a muscarinic receptor antagonist possessing both antimuscarinic and antispasmodic properties. Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, competitively blocks muscarinic receptors, thereby inhibiting acetylcholine binding. This antagonistic action results in an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, indicating an antimuscarinic action on the lower urinary tract. The 5-hydroxymethyl metabolite appears to contribute significantly to the therapeutic effects." @default.
- NCIT_C62083 NCIT_A5 NCIT_C29504 @default.
- NCIT_C62083 NCIT_NHC0 "C62083" @default.
- NCIT_C62083 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62083 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62083 NCIT_P108 "Tolterodine" @default.
- NCIT_C62083 NCIT_P207 "C0388753" @default.
- NCIT_C62083 NCIT_P210 "124937-51-5" @default.
- NCIT_C62083 NCIT_P319 "WHE7A56U7K" @default.
- NCIT_C62083 NCIT_P322 "FDA" @default.
- NCIT_C62083 NCIT_P350 "C22H31NO" @default.
- NCIT_C62083 NCIT_P366 "Tolterodine_Base" @default.
- NCIT_C62083 NCIT_P368 "CHEBI:9622" @default.
- NCIT_C62083 normalizedInformationContent "100" @default.
- NCIT_C62083 referenceCount "1" @default.
- NCIT_C62083 hasExactSynonym "TOLTERODINE" @default.
- NCIT_C62083 hasExactSynonym "Tolterodine" @default.
- NCIT_C62083 inSubset NCIT_C63923 @default.
- NCIT_C62083 type Class @default.
- NCIT_C62083 isDefinedBy ncit.owl @default.
- NCIT_C62083 label "Tolterodine" @default.
- NCIT_C62083 subClassOf NCIT_C1908 @default.
- NCIT_C62083 subClassOf NCIT_C1909 @default.
- NCIT_C62083 subClassOf NCIT_C29704 @default.
- NCIT_C62083 subClassOf NCIT_C62083 @default.
- NCIT_C62083 subClassOf NCIT_C66880 @default.
- NCIT_C62083 subClassOf NCIT_C78272 @default.