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- NCIT_C62179 IAO_0000115 "A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B lineage hematologic malignancies including multiple myeloma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's disease and acute lymphoblastic leukemia." @default.
- NCIT_C62179 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62179 NCIT_NHC0 "C62179" @default.
- NCIT_C62179 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C62179 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C62179 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62179 NCIT_P107 "Dacetuzumab" @default.
- NCIT_C62179 NCIT_P108 "Dacetuzumab" @default.
- NCIT_C62179 NCIT_P207 "C2742509" @default.
- NCIT_C62179 NCIT_P210 "880486-59-9" @default.
- NCIT_C62179 NCIT_P319 "UT59FF4T5X" @default.
- NCIT_C62179 NCIT_P322 "CTRP" @default.
- NCIT_C62179 NCIT_P322 "FDA" @default.
- NCIT_C62179 NCIT_P322 "GDC" @default.
- NCIT_C62179 NCIT_P325 "A monoclonal antibody that binds to cells that have the CD40 antigen on their surface, including cells from multiple myeloma, non-Hodgkin lymphoma, and chronic lymphocytic leukemia. SGN-40 is being studied in the treatment of cancer. It is a type of monoclonal antibody." @default.
- NCIT_C62179 NCIT_P329 "365545" @default.
- NCIT_C62179 NCIT_P330 "365545" @default.
- NCIT_C62179 NCIT_P366 "SGN-40" @default.
- NCIT_C62179 NCIT_P375 "Dacetuzumab" @default.
- NCIT_C62179 NCIT_P399 "365545" @default.
- NCIT_C62179 NCIT_R124 NCIT_C17710 @default.
- NCIT_C62179 NCIT_R124 NCIT_C17828 @default.
- NCIT_C62179 NCIT_R124 NCIT_C18219 @default.
- NCIT_C62179 NCIT_R124 NCIT_C19986 @default.
- NCIT_C62179 NCIT_R124 NCIT_C40474 @default.
- NCIT_C62179 normalizedInformationContent "100" @default.
- NCIT_C62179 referenceCount "1" @default.
- NCIT_C62179 hasExactSynonym "Anti-huCD40 mAb" @default.
- NCIT_C62179 hasExactSynonym "DACETUZUMAB" @default.
- NCIT_C62179 hasExactSynonym "Dacetuzumab" @default.
- NCIT_C62179 hasExactSynonym "Monoclonal Antibody SGN-40" @default.
- NCIT_C62179 hasExactSynonym "SGN-40" @default.
- NCIT_C62179 hasExactSynonym "huS2C6" @default.
- NCIT_C62179 inSubset NCIT_C116977 @default.
- NCIT_C62179 inSubset NCIT_C116978 @default.
- NCIT_C62179 inSubset NCIT_C128784 @default.
- NCIT_C62179 inSubset NCIT_C157711 @default.
- NCIT_C62179 inSubset NCIT_C157712 @default.
- NCIT_C62179 inSubset NCIT_C176424 @default.
- NCIT_C62179 inSubset NCIT_C177537 @default.
- NCIT_C62179 inSubset NCIT_C63923 @default.
- NCIT_C62179 type Class @default.
- NCIT_C62179 isDefinedBy ncit.owl @default.
- NCIT_C62179 label "Dacetuzumab" @default.
- NCIT_C62179 subClassOf NCIT_C129820 @default.
- NCIT_C62179 subClassOf NCIT_C129821 @default.
- NCIT_C62179 subClassOf NCIT_C129822 @default.
- NCIT_C62179 subClassOf NCIT_C133877 @default.
- NCIT_C62179 subClassOf NCIT_C1908 @default.
- NCIT_C62179 subClassOf NCIT_C1909 @default.
- NCIT_C62179 subClassOf NCIT_C191767 @default.
- NCIT_C62179 subClassOf NCIT_C20401 @default.
- NCIT_C62179 subClassOf NCIT_C274 @default.
- NCIT_C62179 subClassOf NCIT_C307 @default.
- NCIT_C62179 subClassOf NCIT_C308 @default.
- NCIT_C62179 subClassOf NCIT_C62179 @default.