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- NCIT_C62482 IAO_0000115 "A humanized agonistic monoclonal antibody directed against human tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) with potential antitumor activity. Mimicking the natural receptor ligand TRAIL, tigatuzumab binds to TRAIL-R2, activating signal transduction pathways that may result in tumor cell apoptosis and a reduction in tumor growth. A member of the tumor necrosis factor (TNF) receptor family, TRAIL-R2, also known as DR5 (death receptor 5), is expressed on the surfaces of many types of malignant cells." @default.
- NCIT_C62482 NCIT_A32 NCIT_C1909 @default.
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- NCIT_C62482 NCIT_NHC0 "C62482" @default.
- NCIT_C62482 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C62482 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C62482 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62482 NCIT_P107 "Tigatuzumab" @default.
- NCIT_C62482 NCIT_P108 "Tigatuzumab" @default.
- NCIT_C62482 NCIT_P207 "C2973415" @default.
- NCIT_C62482 NCIT_P210 "918127-53-4" @default.
- NCIT_C62482 NCIT_P319 "237GB6IDKO" @default.
- NCIT_C62482 NCIT_P322 "CTRP" @default.
- NCIT_C62482 NCIT_P322 "FDA" @default.
- NCIT_C62482 NCIT_P322 "GDC" @default.
- NCIT_C62482 NCIT_P329 "489323" @default.
- NCIT_C62482 NCIT_P330 "489323" @default.
- NCIT_C62482 NCIT_P366 "CS-1008" @default.
- NCIT_C62482 NCIT_P375 "Tigatuzumab" @default.
- NCIT_C62482 NCIT_P399 "489323" @default.
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- NCIT_C62482 NCIT_R125 NCIT_C21124 @default.
- NCIT_C62482 NCIT_R146 NCIT_C17021 @default.
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- NCIT_C62482 NCIT_R146 NCIT_C18106 @default.
- NCIT_C62482 NCIT_R146 NCIT_C18178 @default.
- NCIT_C62482 NCIT_R146 NCIT_C19285 @default.
- NCIT_C62482 NCIT_R146 NCIT_C20027 @default.
- NCIT_C62482 NCIT_R146 NCIT_C26548 @default.
- NCIT_C62482 normalizedInformationContent "100" @default.
- NCIT_C62482 referenceCount "1" @default.
- NCIT_C62482 hasExactSynonym "Anti-DR5 MoAb" @default.
- NCIT_C62482 hasExactSynonym "Anti-TRAIL-R2 MoAb" @default.
- NCIT_C62482 hasExactSynonym "CS-1008" @default.
- NCIT_C62482 hasExactSynonym "TIGATUZUMAB" @default.
- NCIT_C62482 hasExactSynonym "Tigatuzumab" @default.
- NCIT_C62482 hasExactSynonym "anti-[Homo sapiens TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily Member 10B, DR5, TRAIL-R2, CD262)] Humanized Monoclonal TRA-8" @default.
- NCIT_C62482 inSubset NCIT_C116977 @default.
- NCIT_C62482 inSubset NCIT_C116978 @default.
- NCIT_C62482 inSubset NCIT_C128784 @default.
- NCIT_C62482 inSubset NCIT_C157711 @default.
- NCIT_C62482 inSubset NCIT_C157712 @default.
- NCIT_C62482 inSubset NCIT_C176424 @default.
- NCIT_C62482 inSubset NCIT_C177537 @default.
- NCIT_C62482 inSubset NCIT_C63923 @default.
- NCIT_C62482 type Class @default.
- NCIT_C62482 isDefinedBy ncit.owl @default.
- NCIT_C62482 label "Tigatuzumab" @default.
- NCIT_C62482 subClassOf B0ecf6c88dcbf8d594eba4f4e52d4dcc3 @default.
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- NCIT_C62482 subClassOf NCIT_C171189 @default.
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- NCIT_C62482 subClassOf NCIT_C1909 @default.
- NCIT_C62482 subClassOf NCIT_C20401 @default.
- NCIT_C62482 subClassOf NCIT_C307 @default.
- NCIT_C62482 subClassOf NCIT_C308 @default.
- NCIT_C62482 subClassOf NCIT_C574 @default.
- NCIT_C62482 subClassOf NCIT_C62482 @default.