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- NCIT_C62483 IAO_0000115 "A chimeric IgG1 monoclonal antibody against human mesothelin with potential anti-tumor activity. Amatuximab specifically targets mesothelin, a cell surface glycoprotein involved in cell adhesion and overexpressed on many epithelial-derived cancer cells. Upon binding to the mesothelin antigen, amatuximab triggers an antibody dependent cellular cytotoxicity (ADCC)-mediated host immune response against mesothelin-expressing cells, resulting in cell lysis." @default.
- NCIT_C62483 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62483 NCIT_A7 NCIT_C20887 @default.
- NCIT_C62483 NCIT_NHC0 "C62483" @default.
- NCIT_C62483 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C62483 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C62483 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62483 NCIT_P107 "Amatuximab" @default.
- NCIT_C62483 NCIT_P108 "Amatuximab" @default.
- NCIT_C62483 NCIT_P207 "C3179481" @default.
- NCIT_C62483 NCIT_P210 "931402-35-6" @default.
- NCIT_C62483 NCIT_P319 "6HP0354G04" @default.
- NCIT_C62483 NCIT_P322 "CTRP" @default.
- NCIT_C62483 NCIT_P322 "FDA" @default.
- NCIT_C62483 NCIT_P322 "GDC" @default.
- NCIT_C62483 NCIT_P325 "A monoclonal antibody being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-mesothelin monoclonal antibody MORAb-009 binds to mesothelin (a protein that is made by some cancer cells) and stops the cells from dividing." @default.
- NCIT_C62483 NCIT_P329 "489384" @default.
- NCIT_C62483 NCIT_P330 "489384" @default.
- NCIT_C62483 NCIT_P350 "C6394H9870N1694O2024S46" @default.
- NCIT_C62483 NCIT_P366 "Anti-Mesothelin_Monoclonal_Antibody" @default.
- NCIT_C62483 NCIT_P375 "Amatuximab" @default.
- NCIT_C62483 NCIT_P399 "489384" @default.
- NCIT_C62483 NCIT_R124 NCIT_C17710 @default.
- NCIT_C62483 NCIT_R124 NCIT_C17828 @default.
- NCIT_C62483 NCIT_R124 NCIT_C18219 @default.
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- NCIT_C62483 NCIT_R124 NCIT_C40474 @default.
- NCIT_C62483 NCIT_R125 NCIT_C16298 @default.
- NCIT_C62483 NCIT_R125 NCIT_C17709 @default.
- NCIT_C62483 NCIT_R125 NCIT_C17828 @default.
- NCIT_C62483 NCIT_R125 NCIT_C17930 @default.
- NCIT_C62483 NCIT_R125 NCIT_C17937 @default.
- NCIT_C62483 NCIT_R125 NCIT_C18839 @default.
- NCIT_C62483 NCIT_R125 NCIT_C19053 @default.
- NCIT_C62483 NCIT_R125 NCIT_C21124 @default.
- NCIT_C62483 NCIT_R125 NCIT_C26280 @default.
- NCIT_C62483 NCIT_R125 NCIT_C40833 @default.
- NCIT_C62483 NCIT_R146 NCIT_C128316 @default.
- NCIT_C62483 NCIT_R146 NCIT_C16725 @default.
- NCIT_C62483 NCIT_R146 NCIT_C17021 @default.
- NCIT_C62483 NCIT_R146 NCIT_C20027 @default.
- NCIT_C62483 NCIT_R146 NCIT_C20887 @default.
- NCIT_C62483 NCIT_R146 NCIT_C26548 @default.
- NCIT_C62483 normalizedInformationContent "100" @default.
- NCIT_C62483 referenceCount "1" @default.
- NCIT_C62483 hasExactSynonym "AMATUXIMAB" @default.
- NCIT_C62483 hasExactSynonym "Amatuximab" @default.
- NCIT_C62483 hasExactSynonym "Anti-Mesothelin Monoclonal Antibody MORAb-009" @default.
- NCIT_C62483 hasExactSynonym "Immunoglobulin G1, Anti-(mesothelin) (Human-Mouse Monoclonal MORAb-009 Heavy Chain), Disulfide with Human-Mouse Monoclonal MORAb-009 Kappa-Chain, Dimer" @default.
- NCIT_C62483 hasExactSynonym "MORAb-009" @default.
- NCIT_C62483 hasExactSynonym "anti-mesothelin monoclonal antibody MORAb-009" @default.
- NCIT_C62483 inSubset NCIT_C116977 @default.
- NCIT_C62483 inSubset NCIT_C116978 @default.
- NCIT_C62483 inSubset NCIT_C128784 @default.
- NCIT_C62483 inSubset NCIT_C157711 @default.
- NCIT_C62483 inSubset NCIT_C157712 @default.
- NCIT_C62483 inSubset NCIT_C176424 @default.
- NCIT_C62483 inSubset NCIT_C177537 @default.
- NCIT_C62483 inSubset NCIT_C63923 @default.
- NCIT_C62483 type Class @default.
- NCIT_C62483 isDefinedBy ncit.owl @default.
- NCIT_C62483 label "Amatuximab" @default.
- NCIT_C62483 subClassOf B1a55f59d7524bc46f2c6aa1cc0bd5efe @default.
- NCIT_C62483 subClassOf B4b2986bbc6bb264e8629d5404bc8f947 @default.
- NCIT_C62483 subClassOf Badef86a2ee22a33ca39c348d45b0f3d2 @default.
- NCIT_C62483 subClassOf Bb976b42b1df644a1cc9dd31d155b2610 @default.
- NCIT_C62483 subClassOf Bc99f3cbed012b1ea614c256d1362cc74 @default.
- NCIT_C62483 subClassOf Bd4b13f328600f5e6b6709d1e82e09f48 @default.
- NCIT_C62483 subClassOf Bdb0254cbf9da95f7908edde0dc05eac4 @default.
- NCIT_C62483 subClassOf Bdd8a2b8c80c783940c01181c7be781aa @default.
- NCIT_C62483 subClassOf NCIT_C129821 @default.
- NCIT_C62483 subClassOf NCIT_C129822 @default.
- NCIT_C62483 subClassOf NCIT_C1908 @default.
- NCIT_C62483 subClassOf NCIT_C1909 @default.
- NCIT_C62483 subClassOf NCIT_C201534 @default.
- NCIT_C62483 subClassOf NCIT_C20401 @default.
- NCIT_C62483 subClassOf NCIT_C274 @default.
- NCIT_C62483 subClassOf NCIT_C307 @default.
- NCIT_C62483 subClassOf NCIT_C308 @default.
- NCIT_C62483 subClassOf NCIT_C62483 @default.