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- NCIT_C62502 IAO_0000115 "An orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Upon administration and rapid conversion from the prodrug form in plasma, AZD1152-HQPA specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently, cell division and cell proliferation are inhibited and apoptosis is induced in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types." @default.
- NCIT_C62502 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62502 NCIT_A7 NCIT_C68596 @default.
- NCIT_C62502 NCIT_NHC0 "C62502" @default.
- NCIT_C62502 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62502 NCIT_P107 "Barasertib" @default.
- NCIT_C62502 NCIT_P108 "Barasertib" @default.
- NCIT_C62502 NCIT_P207 "C1831923" @default.
- NCIT_C62502 NCIT_P210 "722543-31-9" @default.
- NCIT_C62502 NCIT_P319 "16XC2U7W8N" @default.
- NCIT_C62502 NCIT_P322 "CTRP" @default.
- NCIT_C62502 NCIT_P322 "FDA" @default.
- NCIT_C62502 NCIT_P322 "GDC" @default.
- NCIT_C62502 NCIT_P329 "496937" @default.
- NCIT_C62502 NCIT_P330 "496937" @default.
- NCIT_C62502 NCIT_P350 "C26H31FN7O6P" @default.
- NCIT_C62502 NCIT_P366 "AZD1152" @default.
- NCIT_C62502 NCIT_P375 "Barasertib" @default.
- NCIT_C62502 NCIT_P399 "496937" @default.
- NCIT_C62502 NCIT_R146 NCIT_C16554 @default.
- NCIT_C62502 NCIT_R146 NCIT_C16984 @default.
- NCIT_C62502 NCIT_R146 NCIT_C17018 @default.
- NCIT_C62502 NCIT_R146 NCIT_C17021 @default.
- NCIT_C62502 NCIT_R146 NCIT_C17210 @default.
- NCIT_C62502 NCIT_R146 NCIT_C17325 @default.
- NCIT_C62502 NCIT_R146 NCIT_C20027 @default.
- NCIT_C62502 NCIT_R146 NCIT_C26548 @default.
- NCIT_C62502 NCIT_R146 NCIT_C30006 @default.
- NCIT_C62502 normalizedInformationContent "100" @default.
- NCIT_C62502 referenceCount "1" @default.
- NCIT_C62502 hasExactSynonym "1h-pyrazole-3-acetamide, 5-((7-(3-(ethyl(2-(phosphonooxy)ethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)-" @default.
- NCIT_C62502 hasExactSynonym "AZD-1152" @default.
- NCIT_C62502 hasExactSynonym "AZD1152" @default.
- NCIT_C62502 hasExactSynonym "Aurora Kinase Inhibitor AZD1152" @default.
- NCIT_C62502 hasExactSynonym "BARASERTIB" @default.
- NCIT_C62502 hasExactSynonym "Barasertib" @default.
- NCIT_C62502 inSubset NCIT_C116977 @default.
- NCIT_C62502 inSubset NCIT_C116978 @default.
- NCIT_C62502 inSubset NCIT_C128784 @default.
- NCIT_C62502 inSubset NCIT_C157711 @default.
- NCIT_C62502 inSubset NCIT_C157712 @default.
- NCIT_C62502 inSubset NCIT_C176424 @default.
- NCIT_C62502 inSubset NCIT_C177537 @default.
- NCIT_C62502 inSubset NCIT_C63923 @default.
- NCIT_C62502 type Class @default.
- NCIT_C62502 isDefinedBy ncit.owl @default.
- NCIT_C62502 label "Barasertib" @default.
- NCIT_C62502 subClassOf NCIT_C129824 @default.
- NCIT_C62502 subClassOf NCIT_C129825 @default.
- NCIT_C62502 subClassOf NCIT_C1404 @default.
- NCIT_C62502 subClassOf NCIT_C1908 @default.
- NCIT_C62502 subClassOf NCIT_C1909 @default.
- NCIT_C62502 subClassOf NCIT_C2189 @default.
- NCIT_C62502 subClassOf NCIT_C274 @default.
- NCIT_C62502 subClassOf NCIT_C471 @default.
- NCIT_C62502 subClassOf NCIT_C61074 @default.
- NCIT_C62502 subClassOf NCIT_C62502 @default.
- NCIT_C62502 subClassOf NCIT_C62556 @default.