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- NCIT_C62508 IAO_0000115 "A potent inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. Diazepinomicin binds to and inhibits Ras kinase, thereby preventing the phosphorylation and activation of proteins downstream of the Ras signal transduction pathway, including serine/threonine kinase RAF (BRAF) and extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK-2), that play a crucial role in regulating cell growth and survival. Diazepinomicin also selectively binds to the peripheral benzodiazepine receptor (BZRP), a receptor highly expressed in certain cancer cells, thus inducing cell cycle arrest and apoptosis in BZRP-expressing cells. In addition, diazepinomicin is able to cross the blood-brain barrier, thereby reaching therapeutic concentrations in the brain." @default.
- NCIT_C62508 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62508 NCIT_A7 NCIT_C17484 @default.
- NCIT_C62508 NCIT_NHC0 "C62508" @default.
- NCIT_C62508 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62508 NCIT_P107 "Diazepinomicin" @default.
- NCIT_C62508 NCIT_P108 "Diazepinomicin" @default.
- NCIT_C62508 NCIT_P171 "20655882" @default.
- NCIT_C62508 NCIT_P207 "C4048794" @default.
- NCIT_C62508 NCIT_P210 "733035-26-2" @default.
- NCIT_C62508 NCIT_P319 "YPH994Y0RF" @default.
- NCIT_C62508 NCIT_P322 "CTRP" @default.
- NCIT_C62508 NCIT_P322 "FDA" @default.
- NCIT_C62508 NCIT_P322 "GDC" @default.
- NCIT_C62508 NCIT_P329 "496938" @default.
- NCIT_C62508 NCIT_P330 "496938" @default.
- NCIT_C62508 NCIT_P350 "C28H34N2O4" @default.
- NCIT_C62508 NCIT_P366 "ECO-4601" @default.
- NCIT_C62508 NCIT_P375 "Diazepinomicin" @default.
- NCIT_C62508 NCIT_P399 "496938" @default.
- NCIT_C62508 normalizedInformationContent "100" @default.
- NCIT_C62508 referenceCount "1" @default.
- NCIT_C62508 hasExactSynonym "11h-dibenzo(B,E)(1,4)diazepin-11-one, 5,10-dihydro-4,6,8-trihydroxy-10-((2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-" @default.
- NCIT_C62508 hasExactSynonym "BU-4664L" @default.
- NCIT_C62508 hasExactSynonym "DIAZEPINOMICIN" @default.
- NCIT_C62508 hasExactSynonym "Diazepinomicin" @default.
- NCIT_C62508 hasExactSynonym "ECO-4601" @default.
- NCIT_C62508 hasExactSynonym "TLN-4601" @default.
- NCIT_C62508 inSubset NCIT_C116977 @default.
- NCIT_C62508 inSubset NCIT_C116978 @default.
- NCIT_C62508 inSubset NCIT_C128784 @default.
- NCIT_C62508 inSubset NCIT_C157711 @default.
- NCIT_C62508 inSubset NCIT_C157712 @default.
- NCIT_C62508 inSubset NCIT_C176424 @default.
- NCIT_C62508 inSubset NCIT_C177537 @default.
- NCIT_C62508 inSubset NCIT_C63923 @default.
- NCIT_C62508 type Class @default.
- NCIT_C62508 isDefinedBy ncit.owl @default.
- NCIT_C62508 label "Diazepinomicin" @default.
- NCIT_C62508 subClassOf NCIT_C1012 @default.
- NCIT_C62508 subClassOf NCIT_C1908 @default.
- NCIT_C62508 subClassOf NCIT_C1909 @default.
- NCIT_C62508 subClassOf NCIT_C2189 @default.
- NCIT_C62508 subClassOf NCIT_C274 @default.
- NCIT_C62508 subClassOf NCIT_C28197 @default.
- NCIT_C62508 subClassOf NCIT_C29756 @default.
- NCIT_C62508 subClassOf NCIT_C62508 @default.
- NCIT_C62508 subClassOf NCIT_C78272 @default.