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- NCIT_C62510 IAO_0000115 "A humanized monoclonal antibody directed against C-C chemokine receptor 4 (CCR4) with potential anti-inflammatory and antineoplastic activities. Mogamulizumab selectively binds to and blocks the activity of CCR4, which may inhibit CCR4-mediated signal transduction pathways and, so, chemokine-mediated cellular migration and proliferation of T cells, and chemokine-mediated angiogenesis. In addition, this agent may induce antibody-dependent cell-mediated cytotoxicity (ADCC) against CCR4-positive T cells. CCR4, a G-coupled-protein receptor for C-C chemokines such MIP-1, RANTES, TARC and MCP-1, is expressed on the surfaces of some types of T cells, endothelial cells, and some types of neurons. CCR4, also known as CD194, may be overexpressed on adult T-cell lymphoma (ATL) and peripheral T-cell lymphoma (PTCL) cells." @default.
- NCIT_C62510 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62510 NCIT_A7 NCIT_C129067 @default.
- NCIT_C62510 NCIT_NHC0 "C62510" @default.
- NCIT_C62510 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C62510 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C62510 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62510 NCIT_P107 "Mogamulizumab" @default.
- NCIT_C62510 NCIT_P108 "Mogamulizumab" @default.
- NCIT_C62510 NCIT_P207 "C2987603" @default.
- NCIT_C62510 NCIT_P210 "1159266-37-1" @default.
- NCIT_C62510 NCIT_P302 "relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS)" @default.
- NCIT_C62510 NCIT_P319 "YI437801BE" @default.
- NCIT_C62510 NCIT_P322 "CTRP" @default.
- NCIT_C62510 NCIT_P322 "FDA" @default.
- NCIT_C62510 NCIT_P322 "GDC" @default.
- NCIT_C62510 NCIT_P329 "500479" @default.
- NCIT_C62510 NCIT_P330 "500479" @default.
- NCIT_C62510 NCIT_P366 "KW-0761" @default.
- NCIT_C62510 NCIT_P375 "Mogamulizumab" @default.
- NCIT_C62510 NCIT_P399 "500479" @default.
- NCIT_C62510 NCIT_R124 NCIT_C17710 @default.
- NCIT_C62510 NCIT_R124 NCIT_C17828 @default.
- NCIT_C62510 NCIT_R124 NCIT_C18219 @default.
- NCIT_C62510 NCIT_R124 NCIT_C19986 @default.
- NCIT_C62510 NCIT_R124 NCIT_C40474 @default.
- NCIT_C62510 NCIT_R125 NCIT_C16298 @default.
- NCIT_C62510 NCIT_R125 NCIT_C17709 @default.
- NCIT_C62510 NCIT_R125 NCIT_C17828 @default.
- NCIT_C62510 NCIT_R125 NCIT_C17930 @default.
- NCIT_C62510 NCIT_R125 NCIT_C17937 @default.
- NCIT_C62510 NCIT_R125 NCIT_C18839 @default.
- NCIT_C62510 NCIT_R125 NCIT_C21124 @default.
- NCIT_C62510 NCIT_R72 NCIT_C12219 @default.
- NCIT_C62510 NCIT_R72 NCIT_C12476 @default.
- NCIT_C62510 NCIT_R72 NCIT_C12508 @default.
- NCIT_C62510 NCIT_R72 NCIT_C12535 @default.
- NCIT_C62510 NCIT_R72 NCIT_C21599 @default.
- NCIT_C62510 NCIT_R72 NCIT_C32725 @default.
- NCIT_C62510 NCIT_R72 NCIT_C39567 @default.
- NCIT_C62510 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C62510 referenceCount "2" @default.
- NCIT_C62510 hasExactSynonym "Immunoglobulin G1, Anti-(CC Chemokine Receptor CCR4) (Human-Mouse Monoclonal KW-0761 Heavy Chain), Disulfide With Human-Mouse Monoclonal KW-0761 Kappa-Chain, Dimer" @default.
- NCIT_C62510 hasExactSynonym "KM8761" @default.
- NCIT_C62510 hasExactSynonym "KW-0761" @default.
- NCIT_C62510 hasExactSynonym "MOGAMULIZUMAB" @default.
- NCIT_C62510 hasExactSynonym "Mogamulizumab" @default.
- NCIT_C62510 hasExactSynonym "Mogamulizumab-kpkc" @default.
- NCIT_C62510 hasExactSynonym "Poteligeo" @default.
- NCIT_C62510 inSubset NCIT_C116977 @default.
- NCIT_C62510 inSubset NCIT_C116978 @default.
- NCIT_C62510 inSubset NCIT_C128784 @default.
- NCIT_C62510 inSubset NCIT_C157711 @default.
- NCIT_C62510 inSubset NCIT_C157712 @default.
- NCIT_C62510 inSubset NCIT_C176424 @default.
- NCIT_C62510 inSubset NCIT_C177537 @default.
- NCIT_C62510 inSubset NCIT_C63923 @default.
- NCIT_C62510 type Class @default.
- NCIT_C62510 isDefinedBy ncit.owl @default.
- NCIT_C62510 label "Mogamulizumab" @default.
- NCIT_C62510 subClassOf B3a5965b71904cf5f7598e610a9247140 @default.
- NCIT_C62510 subClassOf B6366da61afdbb8152d595d9b0f0047d6 @default.
- NCIT_C62510 subClassOf B7eac63796afca2ce0ffe889dd99371e1 @default.
- NCIT_C62510 subClassOf B9a907f4458210ca60dbc79b5d9fc31b9 @default.
- NCIT_C62510 subClassOf Ba2265b396792723e149cf3a0d57d439c @default.
- NCIT_C62510 subClassOf Bfe82e1d5a55f6998c15e9a0b516b7ec5 @default.
- NCIT_C62510 subClassOf NCIT_C129821 @default.
- NCIT_C62510 subClassOf NCIT_C129822 @default.
- NCIT_C62510 subClassOf NCIT_C163758 @default.
- NCIT_C62510 subClassOf NCIT_C163950 @default.
- NCIT_C62510 subClassOf NCIT_C163998 @default.
- NCIT_C62510 subClassOf NCIT_C1908 @default.
- NCIT_C62510 subClassOf NCIT_C1909 @default.
- NCIT_C62510 subClassOf NCIT_C20401 @default.
- NCIT_C62510 subClassOf NCIT_C274 @default.
- NCIT_C62510 subClassOf NCIT_C307 @default.
- NCIT_C62510 subClassOf NCIT_C308 @default.
- NCIT_C62510 subClassOf NCIT_C62510 @default.