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- NCIT_C62514 IAO_0000115 "An orally active second generation tetrathiomolybdate analog with anti-angiogenic and antineoplastic activities. Tiomolibdate choline selectively chelates the copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1 of copper and inhibiting its activity. Inhibition of SOD1 interferes with the activation of several signal transduction pathways required for cellular proliferation and angiogenesis, including those mediated by ERK1/2 and FAK and Src kinases. This results in an inhibition of cell proliferation and angiogenesis as well as induction of apoptosis." @default.
- NCIT_C62514 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62514 NCIT_A7 NCIT_C55287 @default.
- NCIT_C62514 NCIT_NHC0 "C62514" @default.
- NCIT_C62514 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62514 NCIT_P108 "Tiomolibdate Choline" @default.
- NCIT_C62514 NCIT_P207 "C1831930" @default.
- NCIT_C62514 NCIT_P210 "649749-10-0" @default.
- NCIT_C62514 NCIT_P319 "FD57A79R4P" @default.
- NCIT_C62514 NCIT_P322 "FDA" @default.
- NCIT_C62514 NCIT_P322 "GDC" @default.
- NCIT_C62514 NCIT_P325 "A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. ATN-224 also blocks enzymes that cells need to divide and grow, and it may kill cancer cells. It is a type of antiangiogenesis agent and a type of superoxide dismutase inhibitor." @default.
- NCIT_C62514 NCIT_P329 "500040" @default.
- NCIT_C62514 NCIT_P330 "500040" @default.
- NCIT_C62514 NCIT_P350 "2C5H14NO.MoS4" @default.
- NCIT_C62514 NCIT_P366 "ATN-224" @default.
- NCIT_C62514 NCIT_P375 "Bis(choline)tetrathiomolybdate" @default.
- NCIT_C62514 NCIT_P375 "Tiomolibdate Choline" @default.
- NCIT_C62514 NCIT_P399 "500040" @default.
- NCIT_C62514 NCIT_R146 NCIT_C16554 @default.
- NCIT_C62514 NCIT_R146 NCIT_C16946 @default.
- NCIT_C62514 NCIT_R146 NCIT_C17021 @default.
- NCIT_C62514 NCIT_R146 NCIT_C17172 @default.
- NCIT_C62514 NCIT_R146 NCIT_C20027 @default.
- NCIT_C62514 NCIT_R146 NCIT_C26548 @default.
- NCIT_C62514 NCIT_R146 NCIT_C55287 @default.
- NCIT_C62514 normalizedInformationContent "100" @default.
- NCIT_C62514 referenceCount "1" @default.
- NCIT_C62514 hasExactSynonym "ALXN-1840" @default.
- NCIT_C62514 hasExactSynonym "ATN 224" @default.
- NCIT_C62514 hasExactSynonym "ATN-224" @default.
- NCIT_C62514 hasExactSynonym "Bis(choline)tetrathiomolybdate" @default.
- NCIT_C62514 hasExactSynonym "Ethanaminium, 2-Hydroxy-N,N,N-Trimethyl-, (T-4)-Tetrathioxomolybdate(2-) (2:1)" @default.
- NCIT_C62514 hasExactSynonym "SOD1 Inhibitor ATN-224" @default.
- NCIT_C62514 hasExactSynonym "SOD1 inhibitor ATN-224" @default.
- NCIT_C62514 hasExactSynonym "TIOMOLIBDATE CHOLINE" @default.
- NCIT_C62514 hasExactSynonym "Tiomolibdate Choline" @default.
- NCIT_C62514 hasExactSynonym "WTX-101" @default.
- NCIT_C62514 hasExactSynonym "WTX101" @default.
- NCIT_C62514 inSubset NCIT_C128784 @default.
- NCIT_C62514 inSubset NCIT_C157711 @default.
- NCIT_C62514 inSubset NCIT_C157712 @default.
- NCIT_C62514 inSubset NCIT_C176424 @default.
- NCIT_C62514 inSubset NCIT_C177537 @default.
- NCIT_C62514 inSubset NCIT_C63923 @default.
- NCIT_C62514 type Class @default.
- NCIT_C62514 isDefinedBy ncit.owl @default.
- NCIT_C62514 label "Tiomolibdate Choline" @default.
- NCIT_C62514 subClassOf B2e5b58a6a8e72f09f57bb247cd308f03 @default.
- NCIT_C62514 subClassOf Bd63718ed57491c5902b2e4536fde2567 @default.
- NCIT_C62514 subClassOf NCIT_C1742 @default.
- NCIT_C62514 subClassOf NCIT_C1908 @default.
- NCIT_C62514 subClassOf NCIT_C1909 @default.
- NCIT_C62514 subClassOf NCIT_C274 @default.
- NCIT_C62514 subClassOf NCIT_C471 @default.
- NCIT_C62514 subClassOf NCIT_C62514 @default.