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- NCIT_C62517 IAO_0000115 "An orally active inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity. HSP90, a chaperon protein upregulated in a variety of tumor cells, regulates the folding and degradation of many oncogenic signaling proteins. HSP90 inhibitor BIIB021 specifically blocks active HSP90, thereby inhibiting its chaperon function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. As a result, CNF2024 has the potential to inhibit the growth of a wide range of cancer cells in both solid tumors and blood-based cancers." @default.
- NCIT_C62517 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62517 NCIT_A7 NCIT_C17766 @default.
- NCIT_C62517 NCIT_NHC0 "C62517" @default.
- NCIT_C62517 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62517 NCIT_P107 "Hsp90 Inhibitor BIIB021" @default.
- NCIT_C62517 NCIT_P108 "Hsp90 Inhibitor BIIB021" @default.
- NCIT_C62517 NCIT_P207 "C1831929" @default.
- NCIT_C62517 NCIT_P210 "848695-25-0" @default.
- NCIT_C62517 NCIT_P319 "851B9FQ7Q0" @default.
- NCIT_C62517 NCIT_P322 "CTRP" @default.
- NCIT_C62517 NCIT_P322 "FDA" @default.
- NCIT_C62517 NCIT_P322 "GDC" @default.
- NCIT_C62517 NCIT_P329 "497050" @default.
- NCIT_C62517 NCIT_P330 "497050" @default.
- NCIT_C62517 NCIT_P350 "C14H15ClN6O" @default.
- NCIT_C62517 NCIT_P366 "CNF2024" @default.
- NCIT_C62517 NCIT_P375 "Hsp90 Inhibitor BIIB021" @default.
- NCIT_C62517 NCIT_P399 "497050" @default.
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- NCIT_C62517 NCIT_R146 NCIT_C20130 @default.
- NCIT_C62517 NCIT_R146 NCIT_C26548 @default.
- NCIT_C62517 normalizedInformationContent "100" @default.
- NCIT_C62517 referenceCount "1" @default.
- NCIT_C62517 hasExactSynonym "BIIB-021" @default.
- NCIT_C62517 hasExactSynonym "BIIB021" @default.
- NCIT_C62517 hasExactSynonym "CNF2024" @default.
- NCIT_C62517 hasExactSynonym "Hsp90 Antagonist CNF2024" @default.
- NCIT_C62517 hasExactSynonym "Hsp90 Inhibitor BIIB021" @default.
- NCIT_C62517 inSubset NCIT_C116977 @default.
- NCIT_C62517 inSubset NCIT_C116978 @default.
- NCIT_C62517 inSubset NCIT_C128784 @default.
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- NCIT_C62517 inSubset NCIT_C63923 @default.
- NCIT_C62517 type Class @default.
- NCIT_C62517 isDefinedBy ncit.owl @default.
- NCIT_C62517 label "Hsp90 Inhibitor BIIB021" @default.
- NCIT_C62517 subClassOf B2840bbf64416834569492bc0486e6775 @default.
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- NCIT_C62517 subClassOf NCIT_C1908 @default.
- NCIT_C62517 subClassOf NCIT_C1909 @default.
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- NCIT_C62517 subClassOf NCIT_C74526 @default.