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- NCIT_C62518 IAO_0000115 "A c-Myc antisense phosphorodiamidate morpholino oligomer (PMO) with potential antineoplastic activity. Phosphorodiamidate morpholino oligomer AVI-4126 binds to c-Myc mRNA and blocks its translation, which may result in the death of tumor cells overexpressing c-Myc. Differing from traditional antisense oligodeoxynucleotides (ODNs), neutrally charged PMOs are composed of subunits of nucleic acid bases linked to a synthetic backbone and, so, are less prone to enzymatic degradation. c-Myc, a proto-oncogene overexpressed in a variety of cancers, is involved in cellular proliferation, differentiation, and apoptosis." @default.
- NCIT_C62518 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62518 NCIT_NHC0 "C62518" @default.
- NCIT_C62518 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C62518 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62518 NCIT_P108 "Phosphorodiamidate Morpholino Oligomer AVI-4126" @default.
- NCIT_C62518 NCIT_P207 "C1450425" @default.
- NCIT_C62518 NCIT_P322 "GDC" @default.
- NCIT_C62518 NCIT_P329 "496940" @default.
- NCIT_C62518 NCIT_P330 "496940" @default.
- NCIT_C62518 NCIT_P366 "AVI-4126" @default.
- NCIT_C62518 NCIT_P375 "Phosphorodiamidate Morpholino Oligomer AVI-4126" @default.
- NCIT_C62518 NCIT_P399 "496940" @default.
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- NCIT_C62518 normalizedInformationContent "100" @default.
- NCIT_C62518 referenceCount "1" @default.
- NCIT_C62518 hasExactSynonym "AVI-4126" @default.
- NCIT_C62518 hasExactSynonym "Oncomyc-NG" @default.
- NCIT_C62518 hasExactSynonym "PMO AVI-4126" @default.
- NCIT_C62518 hasExactSynonym "Phosphorodiamidate Morpholino Oligomer AVI-4126" @default.
- NCIT_C62518 inSubset NCIT_C128784 @default.
- NCIT_C62518 inSubset NCIT_C157711 @default.
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- NCIT_C62518 type Class @default.
- NCIT_C62518 isDefinedBy ncit.owl @default.
- NCIT_C62518 label "Phosphorodiamidate Morpholino Oligomer AVI-4126" @default.
- NCIT_C62518 subClassOf B02e417b2269e1796504dbbc27591437a @default.
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- NCIT_C62518 subClassOf NCIT_C62518 @default.