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- NCIT_C62525 IAO_0000115 "A water-soluble, folate-receptor-targeted conjugate of folate and the vinca alkaloid desacetylvinblastine monohydrazide (DAVLBH) with potential antineoplastic activity. The folate moiety of vintafolide binds to folic acid receptors on the tumor cell surface and the agent is internalized via folate receptor-mediated endocytosis, delivering the tubulin-binding DAVLBH moiety directly into the tumor cell; DAVLBH binding to tubulin results in the disruption of microtubule assembly-disassembly dynamics, cell cycle arrest, and tumor cell apoptosis. Folic acid receptors are frequently upregulated on the surfaces of many tumor cell types. DAVLBH is a derivative of the natural product vinblastine." @default.
- NCIT_C62525 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62525 NCIT_A7 NCIT_C17219 @default.
- NCIT_C62525 NCIT_NHC0 "C62525" @default.
- NCIT_C62525 NCIT_P106 "Organic Chemical" @default.
- NCIT_C62525 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62525 NCIT_P107 "Vintafolide" @default.
- NCIT_C62525 NCIT_P108 "Vintafolide" @default.
- NCIT_C62525 NCIT_P207 "C1831870" @default.
- NCIT_C62525 NCIT_P210 "742092-03-1" @default.
- NCIT_C62525 NCIT_P319 "36O410ZD4I" @default.
- NCIT_C62525 NCIT_P322 "CTRP" @default.
- NCIT_C62525 NCIT_P322 "FDA" @default.
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- NCIT_C62525 NCIT_P329 "488470" @default.
- NCIT_C62525 NCIT_P330 "488470" @default.
- NCIT_C62525 NCIT_P350 "C86H109N21O26S2" @default.
- NCIT_C62525 NCIT_P366 "EC145" @default.
- NCIT_C62525 NCIT_P375 "Vintafolide" @default.
- NCIT_C62525 NCIT_P399 "488470" @default.
- NCIT_C62525 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C62525 NCIT_R146 NCIT_C26548 @default.
- NCIT_C62525 normalizedInformationContent "100" @default.
- NCIT_C62525 referenceCount "1" @default.
- NCIT_C62525 hasExactSynonym "EC145" @default.
- NCIT_C62525 hasExactSynonym "Folate-Vinca Alkaloid Conjugate EC145" @default.
- NCIT_C62525 hasExactSynonym "VINTAFOLIDE" @default.
- NCIT_C62525 hasExactSynonym "Vintafolide" @default.
- NCIT_C62525 inSubset NCIT_C116977 @default.
- NCIT_C62525 inSubset NCIT_C116978 @default.
- NCIT_C62525 inSubset NCIT_C128784 @default.
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- NCIT_C62525 inSubset NCIT_C177537 @default.
- NCIT_C62525 inSubset NCIT_C63923 @default.
- NCIT_C62525 type Class @default.
- NCIT_C62525 isDefinedBy ncit.owl @default.
- NCIT_C62525 label "Vintafolide" @default.
- NCIT_C62525 subClassOf B0dd9884dc997112ff39d76ff98a90b62 @default.
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- NCIT_C62525 subClassOf NCIT_C1908 @default.
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- NCIT_C62525 subClassOf NCIT_C273 @default.
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- NCIT_C62525 subClassOf NCIT_C67422 @default.