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- NCIT_C62537 IAO_0000115 "A stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities. Mimicking endogenous GSSG, glutathione disulfide NOV-002 acts as a competitive substrate for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and ER stress-induced apoptosis; S-glutathionylation may be stimulated by reactive oxygen species (ROS) liberated by a glutathione disulfide NOV-002-induced increase in GGT activity. Glutathione disulfide NOV-002 may also induce phosphorylation of proteins such as ERK and p38, two kinases that play critical regulatory roles in cell proliferation and apoptosis. The cisplatin component of this agent does not provide an effective therapeutic concentration of cisplatin in vivo." @default.
- NCIT_C62537 NCIT_NHC0 "C62537" @default.
- NCIT_C62537 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62537 NCIT_P107 "Glutathione Disulfide NOV-002" @default.
- NCIT_C62537 NCIT_P108 "Glutathione Disulfide NOV-002" @default.
- NCIT_C62537 NCIT_P207 "C1138321" @default.
- NCIT_C62537 NCIT_P210 "103239-24-3" @default.
- NCIT_C62537 NCIT_P319 "GY131TX61G" @default.
- NCIT_C62537 NCIT_P322 "CTRP" @default.
- NCIT_C62537 NCIT_P322 "FDA" @default.
- NCIT_C62537 NCIT_P329 "494994" @default.
- NCIT_C62537 NCIT_P330 "494994" @default.
- NCIT_C62537 NCIT_P366 "NOV-002" @default.
- NCIT_C62537 NCIT_P399 "494994" @default.
- NCIT_C62537 normalizedInformationContent "100" @default.
- NCIT_C62537 referenceCount "1" @default.
- NCIT_C62537 hasExactSynonym "Glutathione Disulfide NOV-002" @default.
- NCIT_C62537 hasExactSynonym "Glutoxim" @default.
- NCIT_C62537 hasExactSynonym "NOV-002" @default.
- NCIT_C62537 hasExactSynonym "OXIGLUTATIONE DISODIUM" @default.
- NCIT_C62537 hasExactSynonym "Oxidized Glutathione NOV-002" @default.
- NCIT_C62537 inSubset NCIT_C116977 @default.
- NCIT_C62537 inSubset NCIT_C116978 @default.
- NCIT_C62537 inSubset NCIT_C176424 @default.
- NCIT_C62537 inSubset NCIT_C63923 @default.
- NCIT_C62537 type Class @default.
- NCIT_C62537 isDefinedBy ncit.owl @default.
- NCIT_C62537 label "Glutathione Disulfide NOV-002" @default.
- NCIT_C62537 subClassOf NCIT_C129839 @default.
- NCIT_C62537 subClassOf NCIT_C1908 @default.
- NCIT_C62537 subClassOf NCIT_C1909 @default.
- NCIT_C62537 subClassOf NCIT_C274 @default.
- NCIT_C62537 subClassOf NCIT_C62537 @default.