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- NCIT_C62538 IAO_0000115 "A nanoparticle delivery system for recombinant human tumor necrosis factor (TNF) consisting of recombinant TNF bound to pegylated colloidal gold nanoparticles with potential antineoplastic activity. Upon intravenous administration, colloidal gold-bound recombinant human TNF travels through the bloodstream, avoiding immune detection and uptake by the reticuloendothelial system because of nanoparticle pegylation. Due to their size, the colloidal gold nanoparticles exit the circulatory system only at hyperpermeable tumor neovasculature sites; TNF then binds to and activates tumor cell TNF receptors, which may result in an increase in tumor cell apoptosis and a reduction in tumor cell proliferation. Compared to the administration of unbound TNF, colloidal gold-bound TNF may improve the efficacy and safety of TNF administration by delivering TNF specifically to tumor tissue." @default.
- NCIT_C62538 NCIT_A32 NCIT_C1909 @default.
- NCIT_C62538 NCIT_NHC0 "C62538" @default.
- NCIT_C62538 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C62538 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62538 NCIT_P108 "Colloidal Gold-Bound Tumor Necrosis Factor" @default.
- NCIT_C62538 NCIT_P207 "C1831911" @default.
- NCIT_C62538 NCIT_P322 "GDC" @default.
- NCIT_C62538 NCIT_P325 "A substance being studied in the treatment of some types of cancer. Aurimmune is made in the laboratory by binding a cancer-killing protein called tumor necrosis factor (TNF) to the surface of very tiny particles of gold. These TNF-gold particles may kill cancer cells without harming healthy tissue." @default.
- NCIT_C62538 NCIT_P329 "492715" @default.
- NCIT_C62538 NCIT_P330 "492715" @default.
- NCIT_C62538 NCIT_P366 "Colloidal_Gold-Bound_Tumor_Necrosis_Factor" @default.
- NCIT_C62538 NCIT_P375 "Colloidal Gold-Bound Tumor Necrosis Factor" @default.
- NCIT_C62538 NCIT_P399 "492715" @default.
- NCIT_C62538 NCIT_R124 NCIT_C17828 @default.
- NCIT_C62538 NCIT_R124 NCIT_C18992 @default.
- NCIT_C62538 NCIT_R124 NCIT_C19143 @default.
- NCIT_C62538 NCIT_R124 NCIT_C21124 @default.
- NCIT_C62538 NCIT_R124 NCIT_C40702 @default.
- NCIT_C62538 NCIT_R124 NCIT_C45547 @default.
- NCIT_C62538 NCIT_R125 NCIT_C17828 @default.
- NCIT_C62538 NCIT_R125 NCIT_C20150 @default.
- NCIT_C62538 NCIT_R125 NCIT_C20480 @default.
- NCIT_C62538 NCIT_R125 NCIT_C40715 @default.
- NCIT_C62538 NCIT_R125 NCIT_C41515 @default.
- NCIT_C62538 NCIT_R125 NCIT_C51037 @default.
- NCIT_C62538 normalizedInformationContent "100" @default.
- NCIT_C62538 referenceCount "1" @default.
- NCIT_C62538 hasExactSynonym "Aurimmune" @default.
- NCIT_C62538 hasExactSynonym "CYT-6091" @default.
- NCIT_C62538 hasExactSynonym "Colloidal Gold-Bound Recombinant Human Tumor Necrosis Factor" @default.
- NCIT_C62538 hasExactSynonym "Colloidal Gold-Bound Tumor Necrosis Factor" @default.
- NCIT_C62538 hasExactSynonym "TNF-bound colloidal gold" @default.
- NCIT_C62538 hasExactSynonym "colloidal gold-bound TNF" @default.
- NCIT_C62538 hasExactSynonym "colloidal gold-bound rhTNF" @default.
- NCIT_C62538 hasExactSynonym "colloidal gold-bound tumor necrosis factor" @default.
- NCIT_C62538 inSubset NCIT_C128784 @default.
- NCIT_C62538 inSubset NCIT_C157711 @default.
- NCIT_C62538 inSubset NCIT_C157712 @default.
- NCIT_C62538 inSubset NCIT_C176424 @default.
- NCIT_C62538 inSubset NCIT_C177537 @default.
- NCIT_C62538 type Class @default.
- NCIT_C62538 isDefinedBy ncit.owl @default.
- NCIT_C62538 label "Colloidal Gold-Bound Tumor Necrosis Factor" @default.
- NCIT_C62538 subClassOf B373e71da28476fe151cae91094dafd8b @default.
- NCIT_C62538 subClassOf B7d4b2589b271ca0036bc16d6cd944c37 @default.
- NCIT_C62538 subClassOf Ba71959a333b0cdf952e3ea526b64f367 @default.
- NCIT_C62538 subClassOf Bbdacd8b93c8793bb36249683327e4feb @default.
- NCIT_C62538 subClassOf NCIT_C1283 @default.
- NCIT_C62538 subClassOf NCIT_C1908 @default.
- NCIT_C62538 subClassOf NCIT_C1909 @default.
- NCIT_C62538 subClassOf NCIT_C1941 @default.
- NCIT_C62538 subClassOf NCIT_C307 @default.
- NCIT_C62538 subClassOf NCIT_C308 @default.
- NCIT_C62538 subClassOf NCIT_C62538 @default.