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- NCIT_C62555 IAO_0000115 "A recombinant therapeutic agent that is identical or similar to an 84-amino-acid polypeptide produced by the parathyroid gland which functions to maintain a constant concentration of calcium ions (Ca2+) in the extracellular fluid. In target tissues, parathyroid hormone (PTH) binds to and activates the PTH receptor (PTHR), a cell surface G protein-coupled receptor; there are two types of receptors, PTHR1 found in bone and the kidney and PTHR2 found primarily in the central nervous system (CNS), pancreas, testis, and placenta. Activation of PTHRs results in the activation of adenylyl cyclase and phospholipase C in target tissue cells, which, depending upon the specific target tissue, results in the enhancement of intestinal Ca2+ absorption, mobilization of bone Ca2+, and renal Ca2+ reabsorption." @default.
- NCIT_C62555 NCIT_A7 NCIT_C12568 @default.
- NCIT_C62555 NCIT_NHC0 "C62555" @default.
- NCIT_C62555 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C62555 NCIT_P107 "Recombinant Parathyroid Hormone" @default.
- NCIT_C62555 NCIT_P108 "Recombinant Parathyroid Hormone" @default.
- NCIT_C62555 NCIT_P207 "C1882913" @default.
- NCIT_C62555 NCIT_P210 "9002-64-6" @default.
- NCIT_C62555 NCIT_P319 "N19A0T0E5J" @default.
- NCIT_C62555 NCIT_P322 "CTRP" @default.
- NCIT_C62555 NCIT_P322 "FDA" @default.
- NCIT_C62555 NCIT_P329 "489119" @default.
- NCIT_C62555 NCIT_P330 "489119" @default.
- NCIT_C62555 NCIT_P366 "Recombinant_Parathyroid_Hormone" @default.
- NCIT_C62555 NCIT_P399 "489119" @default.
- NCIT_C62555 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C62555 referenceCount "5" @default.
- NCIT_C62555 hasExactSynonym "PARATHYROID HORMONE" @default.
- NCIT_C62555 hasExactSynonym "Recombinant Parathyroid Hormone" @default.
- NCIT_C62555 inSubset NCIT_C116977 @default.
- NCIT_C62555 inSubset NCIT_C116978 @default.
- NCIT_C62555 inSubset NCIT_C176424 @default.
- NCIT_C62555 inSubset NCIT_C63923 @default.
- NCIT_C62555 type Class @default.
- NCIT_C62555 isDefinedBy ncit.owl @default.
- NCIT_C62555 label "Recombinant Parathyroid Hormone" @default.
- NCIT_C62555 subClassOf NCIT_C147908 @default.
- NCIT_C62555 subClassOf NCIT_C1908 @default.
- NCIT_C62555 subClassOf NCIT_C1909 @default.
- NCIT_C62555 subClassOf NCIT_C548 @default.
- NCIT_C62555 subClassOf NCIT_C62555 @default.