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Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C62783> ?p ?o ?g. }

• NCIT_C62783 IAO_0000115 "An orally available small molecule and cyclin-dependent kinase (CDK) inhibitor with potential apoptotic and antineoplastic activity. CDKs, serine/threonine kinases that play an important role in cell cycle regulation, are overexpressed in various malignancies. Seliciclib primarily inhibits CDK 2, 7, and 9 by competing for the ATP binding sites on these kinases, leading to a disruption of cell cycle progression. In addition, this agent seems to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, thereby inhibiting RNA polymerase II-dependent transcription. This may lead to the down-regulation of anti-apoptotic factors, such as myeloid cell leukemia sequence 1 (Mcl-1), a protein crucial for the survival of a range of tumor cell types. The down-regulation of anti-apoptotic factors may lead to an induction of apoptosis, thereby further contributing to seliciclib's antiproliferative effects." @default.
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• NCIT_C62783 NCIT_NHC0 "C62783" @default.
• NCIT_C62783 NCIT_P106 "Organic Chemical" @default.
• NCIT_C62783 NCIT_P106 "Pharmacologic Substance" @default.
• NCIT_C62783 NCIT_P107 "Seliciclib" @default.
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• NCIT_C62783 hasExactSynonym "CYC202" @default.
• NCIT_C62783 hasExactSynonym "R-roscovitine" @default.
• NCIT_C62783 hasExactSynonym "SELICICLIB" @default.
• NCIT_C62783 hasExactSynonym "Seliciclib" @default.
• NCIT_C62783 inSubset NCIT_C116977 @default.
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• NCIT_C62783 type Class @default.
• NCIT_C62783 isDefinedBy ncit.owl @default.
• NCIT_C62783 label "Seliciclib" @default.
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• NCIT_C62783 subClassOf NCIT_C1908 @default.
• NCIT_C62783 subClassOf NCIT_C1909 @default.
• NCIT_C62783 subClassOf NCIT_C2185 @default.

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