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- NCIT_C63477 IAO_0000115 "An oral formulation of the hydrochloride salt of topotecan, a semisynthetic derivative of the quinoline alkaloid camptothecin, with potential antineoplastic activity. Topotecan selectively inhibits topoisomerase I activity by stabilizing topoisomerase I-DNA covalent complexes during the S phase of the cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery." @default.
- NCIT_C63477 NCIT_A32 NCIT_C1909 @default.
- NCIT_C63477 NCIT_NHC0 "C63477" @default.
- NCIT_C63477 NCIT_P106 "Organic Chemical" @default.
- NCIT_C63477 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C63477 NCIT_P107 "Oral Topotecan Hydrochloride" @default.
- NCIT_C63477 NCIT_P108 "Oral Topotecan Hydrochloride" @default.
- NCIT_C63477 NCIT_P207 "C1831879" @default.
- NCIT_C63477 NCIT_P322 "CTRP" @default.
- NCIT_C63477 NCIT_P322 "GDC" @default.
- NCIT_C63477 NCIT_P329 "489122" @default.
- NCIT_C63477 NCIT_P330 "489122" @default.
- NCIT_C63477 NCIT_P366 "Oral_Topotecan_Hydrochloride" @default.
- NCIT_C63477 NCIT_P375 "Oral Topotecan Hydrochloride" @default.
- NCIT_C63477 NCIT_P399 "489122" @default.
- NCIT_C63477 NCIT_R124 NCIT_C17710 @default.
- NCIT_C63477 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C63477 NCIT_R125 NCIT_C17828 @default.
- NCIT_C63477 NCIT_R125 NCIT_C18264 @default.
- NCIT_C63477 NCIT_R125 NCIT_C19154 @default.
- NCIT_C63477 NCIT_R125 NCIT_C21080 @default.
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- NCIT_C63477 NCIT_R125 NCIT_C41543 @default.
- NCIT_C63477 NCIT_R146 NCIT_C16516 @default.
- NCIT_C63477 NCIT_R146 NCIT_C16554 @default.
- NCIT_C63477 NCIT_R146 NCIT_C16759 @default.
- NCIT_C63477 NCIT_R146 NCIT_C17021 @default.
- NCIT_C63477 NCIT_R146 NCIT_C20027 @default.
- NCIT_C63477 NCIT_R146 NCIT_C20646 @default.
- NCIT_C63477 NCIT_R146 NCIT_C26548 @default.
- NCIT_C63477 normalizedInformationContent "100" @default.
- NCIT_C63477 referenceCount "1" @default.
- NCIT_C63477 hasExactSynonym "(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'; 6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride" @default.
- NCIT_C63477 hasExactSynonym "Oral Hycamtin" @default.
- NCIT_C63477 hasExactSynonym "Oral Topotecan Hydrochloride" @default.
- NCIT_C63477 inSubset NCIT_C116977 @default.
- NCIT_C63477 inSubset NCIT_C116978 @default.
- NCIT_C63477 inSubset NCIT_C128784 @default.
- NCIT_C63477 inSubset NCIT_C157711 @default.
- NCIT_C63477 inSubset NCIT_C157712 @default.
- NCIT_C63477 inSubset NCIT_C176424 @default.
- NCIT_C63477 inSubset NCIT_C177537 @default.
- NCIT_C63477 type Class @default.
- NCIT_C63477 isDefinedBy ncit.owl @default.
- NCIT_C63477 label "Oral Topotecan Hydrochloride" @default.
- NCIT_C63477 subClassOf B21e97df0248ddf023daf154ca190e2e2 @default.
- NCIT_C63477 subClassOf B3a4b4b01f88971f8d26136adf01cc0de @default.
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- NCIT_C63477 subClassOf NCIT_C129824 @default.
- NCIT_C63477 subClassOf NCIT_C129825 @default.
- NCIT_C63477 subClassOf NCIT_C1748 @default.
- NCIT_C63477 subClassOf NCIT_C1904 @default.
- NCIT_C63477 subClassOf NCIT_C1908 @default.
- NCIT_C63477 subClassOf NCIT_C1909 @default.
- NCIT_C63477 subClassOf NCIT_C2189 @default.
- NCIT_C63477 subClassOf NCIT_C274 @default.
- NCIT_C63477 subClassOf NCIT_C471 @default.
- NCIT_C63477 subClassOf NCIT_C63477 @default.