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- NCIT_C63478 IAO_0000115 "An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in cell cycle arrest at the G2-M phase and leads to apoptosis within fast growing tumor cells. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Compared to intravenously administered ixabepilone, the oral formulation provides a more manageable way to administer this agent." @default.
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- NCIT_C63478 NCIT_P108 "Oral Ixabepilone" @default.
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- NCIT_C63478 hasExactSynonym "Oral Ixabepilone" @default.
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- NCIT_C63478 type Class @default.
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- NCIT_C63478 label "Oral Ixabepilone" @default.
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