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- NCIT_C63546 IAO_0000115 "A pan-specific, recombinant, fully human monoclonal antibody directed against human transforming growth factor (TGF) -beta 1, 2 and 3 with potential antineoplastic activity. Fresolimumab binds to and inhibits the activity of all isoforms of TGF-beta, which may result in the inhibition of tumor cell growth, angiogenesis, and migration. TGF-beta, a cytokine often over-expressed in various malignancies, may play an important role in promoting the growth, progression, and migration of tumor cells." @default.
- NCIT_C63546 NCIT_A32 NCIT_C1909 @default.
- NCIT_C63546 NCIT_A7 NCIT_C20455 @default.
- NCIT_C63546 NCIT_NHC0 "C63546" @default.
- NCIT_C63546 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C63546 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C63546 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C63546 NCIT_P107 "Fresolimumab" @default.
- NCIT_C63546 NCIT_P108 "Fresolimumab" @default.
- NCIT_C63546 NCIT_P207 "C2987643" @default.
- NCIT_C63546 NCIT_P210 "948564-73-6" @default.
- NCIT_C63546 NCIT_P302 "Idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, and cancer" @default.
- NCIT_C63546 NCIT_P319 "375142VBIA" @default.
- NCIT_C63546 NCIT_P322 "CTRP" @default.
- NCIT_C63546 NCIT_P322 "FDA" @default.
- NCIT_C63546 NCIT_P322 "GDC" @default.
- NCIT_C63546 NCIT_P325 "A monoclonal antibody being studied in the treatment of kidney cancer, melanoma, and pulmonary fibrosis. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-TGF-beta monoclonal antibody GC1008 binds to the protein transforming growth factor-beta (TGF?) and may block the growth of cancer cells that make it." @default.
- NCIT_C63546 NCIT_P329 "530302" @default.
- NCIT_C63546 NCIT_P330 "530302" @default.
- NCIT_C63546 NCIT_P366 "Anti-TGF-Beta_Monoclonal_Antibody_GC1008" @default.
- NCIT_C63546 NCIT_P375 "Fresolimumab" @default.
- NCIT_C63546 NCIT_P399 "530302" @default.
- NCIT_C63546 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C63546 NCIT_R125 NCIT_C19053 @default.
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- NCIT_C63546 NCIT_R146 NCIT_C17021 @default.
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- NCIT_C63546 NCIT_R146 NCIT_C20424 @default.
- NCIT_C63546 NCIT_R146 NCIT_C20455 @default.
- NCIT_C63546 NCIT_R146 NCIT_C26548 @default.
- NCIT_C63546 normalizedInformationContent "100" @default.
- NCIT_C63546 referenceCount "1" @default.
- NCIT_C63546 hasExactSynonym "Anti-TGF-Beta Monoclonal Antibody GC1008" @default.
- NCIT_C63546 hasExactSynonym "FRESOLIMUMAB" @default.
- NCIT_C63546 hasExactSynonym "Fresolimumab" @default.
- NCIT_C63546 hasExactSynonym "GC1008" @default.
- NCIT_C63546 hasExactSynonym "Human Anti-TGF-Beta Monoclonal Antibody GC1008" @default.
- NCIT_C63546 hasExactSynonym "Immunoglobulin G4, anti-(transforming growth factor beta) (human monoclonal GC-1008 heavy chain), disulfide with human monoclonal GC-1008 light chain, Dimer" @default.
- NCIT_C63546 hasExactSynonym "anti-TGF-beta monoclonal antibody GC1008" @default.
- NCIT_C63546 inSubset NCIT_C116977 @default.
- NCIT_C63546 inSubset NCIT_C116978 @default.
- NCIT_C63546 inSubset NCIT_C128784 @default.
- NCIT_C63546 inSubset NCIT_C157711 @default.
- NCIT_C63546 inSubset NCIT_C157712 @default.
- NCIT_C63546 inSubset NCIT_C176424 @default.
- NCIT_C63546 inSubset NCIT_C177537 @default.
- NCIT_C63546 inSubset NCIT_C63923 @default.
- NCIT_C63546 type Class @default.
- NCIT_C63546 isDefinedBy ncit.owl @default.
- NCIT_C63546 label "Fresolimumab" @default.
- NCIT_C63546 subClassOf B1913b59436e7ad59669078b501cd9aa7 @default.
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- NCIT_C63546 subClassOf NCIT_C129821 @default.
- NCIT_C63546 subClassOf NCIT_C129822 @default.
- NCIT_C63546 subClassOf NCIT_C1908 @default.
- NCIT_C63546 subClassOf NCIT_C1909 @default.
- NCIT_C63546 subClassOf NCIT_C20401 @default.
- NCIT_C63546 subClassOf NCIT_C274 @default.
- NCIT_C63546 subClassOf NCIT_C307 @default.
- NCIT_C63546 subClassOf NCIT_C308 @default.
- NCIT_C63546 subClassOf NCIT_C63546 @default.