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- NCIT_C63653 IAO_0000115 "A natural and synthetic xanthophyll and nonprovitamin A carotenoid, with potential antioxidant, anti-inflammatory and antineoplastic activities. Upon administration, astaxanthin may act as an antioxidant and reduce oxidative stress, thereby preventing protein and lipid oxidation and DNA damage. By decreasing the production of reactive oxygen species (ROS) and free radicals, it may also prevent ROS-induced activation of nuclear factor-kappa B (NF-kB) transcription factor and the production of inflammatory cytokines such as interleukin-1beta (IL-1b), IL-6 and tumor necrosis factor-alpha (TNF-a). In addition, astaxanthin may inhibit cyclooxygenase-1 (COX-1) and nitric oxide (NO) activities, thereby reducing inflammation. Oxidative stress and inflammation play key roles in the pathogenesis of many diseases, including cardiovascular, neurological, autoimmune and neoplastic diseases." @default.
- NCIT_C63653 NCIT_NHC0 "C63653" @default.
- NCIT_C63653 NCIT_P106 "Organic Chemical" @default.
- NCIT_C63653 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C63653 NCIT_P108 "Astaxanthin" @default.
- NCIT_C63653 NCIT_P207 "C0052565" @default.
- NCIT_C63653 NCIT_P210 "472-61-7" @default.
- NCIT_C63653 NCIT_P319 "8XPW32PR7I" @default.
- NCIT_C63653 NCIT_P322 "CRCH" @default.
- NCIT_C63653 NCIT_P322 "FDA" @default.
- NCIT_C63653 NCIT_P325 "Carotenoid having a chemical structure similar to beta-carotene with hydroxyl groups at the number 3 and 3' carbon atoms and carbonyl (C=O) functions at the number 4 and 4' carbon atoms." @default.
- NCIT_C63653 NCIT_P329 "801793" @default.
- NCIT_C63653 NCIT_P330 "801793" @default.
- NCIT_C63653 NCIT_P350 "C40H52O4" @default.
- NCIT_C63653 NCIT_P355 "mcg" @default.
- NCIT_C63653 NCIT_P366 "Astaxanthin" @default.
- NCIT_C63653 NCIT_P366 "Astaxanthine" @default.
- NCIT_C63653 NCIT_P368 "CHEBI:40968" @default.
- NCIT_C63653 NCIT_P399 "801793" @default.
- NCIT_C63653 normalizedInformationContent "100" @default.
- NCIT_C63653 referenceCount "1" @default.
- NCIT_C63653 hasExactSynonym "(3S,3'S)-3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione" @default.
- NCIT_C63653 hasExactSynonym "ASTAXANTHIN" @default.
- NCIT_C63653 hasExactSynonym "Astaxanthin" @default.
- NCIT_C63653 hasExactSynonym "Astaxanthine" @default.
- NCIT_C63653 inSubset NCIT_C176424 @default.
- NCIT_C63653 inSubset NCIT_C63923 @default.
- NCIT_C63653 type Class @default.
- NCIT_C63653 isDefinedBy ncit.owl @default.
- NCIT_C63653 label "Astaxanthin" @default.
- NCIT_C63653 subClassOf NCIT_C1908 @default.
- NCIT_C63653 subClassOf NCIT_C1909 @default.
- NCIT_C63653 subClassOf NCIT_C1930 @default.
- NCIT_C63653 subClassOf NCIT_C1949 @default.
- NCIT_C63653 subClassOf NCIT_C210 @default.
- NCIT_C63653 subClassOf NCIT_C2140 @default.
- NCIT_C63653 subClassOf NCIT_C308 @default.
- NCIT_C63653 subClassOf NCIT_C351 @default.
- NCIT_C63653 subClassOf NCIT_C54060 @default.
- NCIT_C63653 subClassOf NCIT_C63653 @default.
- NCIT_C63653 subClassOf NCIT_C68307 @default.
- NCIT_C63653 subClassOf NCIT_C68309 @default.
- NCIT_C63653 subClassOf NCIT_C68542 @default.